Di Leo M A S, Santini S A, Cercone S, Lepore D, Gentiloni Silveri N, Caputo S, Greco A V, Giardina B, Franconi F, Ghirlanda G
Department of Emergency Medicine, Catholic University, Rome, Italy.
Amino Acids. 2002;23(4):401-6. doi: 10.1007/s00726-002-0202-2.
This study evaluates the effect of 4 months supplementation with 2% and 5% taurine (w/w) on the retina of diabetic rats. In non-diabetic rats, taurine does not modify glycemia, body weight, retinal conjugated dienes (CD), lipid hydroperoxide (LP), and Na(+)K(+)ATPase activity. In diabetic rat, at 2, 4, 8, 16 weeks following the onset of diabetes, retinal CD and LP are significantly and progressively increased, while pump activity is gradually and significantly reduced. In taurine supplemented diabetic rats, glycemia is not affected but lipid peroxidation is significantly decreased. Finally, taurine preserves ATPase activity being 5% more effective than 2% taurine. We conclude that taurine supplementation ameliorates biochemical retinal abnormalities caused by diabetes, thereby suggesting that taurine may have a role in the prevention of retinal changes in diabetes.
本研究评估了为期4个月补充2%和5%（w/w）牛磺酸对糖尿病大鼠视网膜的影响。在非糖尿病大鼠中，牛磺酸不会改变血糖、体重、视网膜共轭二烯（CD）、脂质氢过氧化物（LP）以及钠钾ATP酶活性。在糖尿病大鼠中，糖尿病发病后2周、4周、8周、16周时，视网膜CD和LP显著且逐渐增加，而泵活性则逐渐且显著降低。在补充牛磺酸的糖尿病大鼠中，血糖未受影响，但脂质过氧化显著降低。最后，牛磺酸可维持ATP酶活性，5%牛磺酸比2%牛磺酸更有效。我们得出结论，补充牛磺酸可改善糖尿病引起的视网膜生化异常，从而表明牛磺酸可能在预防糖尿病视网膜病变方面发挥作用。
