儿童早期血清胃泌素水平。
Serum gastrin level in early childhood.
作者信息
Sann L, Chayvialle A P, Bremond A, Lambert R
出版信息
Arch Dis Child. 1975 Oct;50(10):782-5. doi: 10.1136/adc.50.10.782.
Serum gastrin concentration was measured in newborns and infants with no gastrointestinal disorders, in the fasting state and after food stimulation. Mean fasting concentration in 14 newborns aged 1 to 12 days (130 . 4 pg/ml +/- 11 . 4 SE) was significantly higher than the mean value in 23 infants aged 1.5 to 22 months (101.4 +/- 6.6 pg/ml). Ingestion of the usual milk meal resulted in a definite rise of the serum gastrin level in the 5 subjects tested (3 newborns and 2 infants). The mean fasting serum gastrin level in 6 babies with hiatus hernia and gastro-oesophageal reflux was found to be no different from the corresponding value in 8 age-matched controls. However, a conspicuously raised fasting gastrin concentration was observed in one infant with lower oesophageal dyskinesia. The results indicate that the release of gastrin and the reactivity of the hormone-producing sites to food stimulation in early life are similar to those in adult humans. No defect of gastrin release was shown in patients with gastro-oesophageal reflux.
在空腹状态及食物刺激后，对无胃肠道疾病的新生儿和婴儿测定血清胃泌素浓度。14名年龄在1至12天的新生儿的平均空腹浓度（130.4 pg/ml±11.4 SE）显著高于23名年龄在1.5至22个月的婴儿的平均值（101.4±6.6 pg/ml）。在所测试的5名受试者（3名新生儿和2名婴儿）中，摄入常规奶餐导致血清胃泌素水平明显升高。发现6名患有食管裂孔疝和胃食管反流的婴儿的平均空腹血清胃泌素水平与8名年龄匹配的对照者的相应值无差异。然而，在1名患有食管下段运动障碍的婴儿中观察到空腹胃泌素浓度明显升高。结果表明，生命早期胃泌素的释放以及激素产生部位对食物刺激的反应性与成年人相似。胃食管反流患者未显示胃泌素释放缺陷。
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