特发性肥厚性幽门狭窄患者血清免疫反应性胃泌素水平升高。
Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis.
作者信息
Bleicher M A, Shandling B, Zingg W, Karl H W, Track N S
出版信息
Gut. 1978 Sep;19(9):794-7. doi: 10.1136/gut.19.9.794.
The serum immunoreactive gastrin (IRG) level in infants with confirmed idiopathic hypertrophic pyloric stenosis (IHPS) has been determined and compared to that found in vomiting infants without IHPS, in normal infants, and in normal adults. The mean serum IRG level of normal infants (103 +/- 9 pg/ml (mean +/- SEM) exceeded that of normal adults (28 +/- 5 pg/ml). The preoperative mean serum IRG level in IHPS infants (256 +/- 26 pg/ml) was significantly higher than that of both normal infants and vomiting infants without IHPS (93 +/- 9 pg/ml). Twenty-five per cent (5/20) of the IHPS infants had serum IRG levels within the upper range of normal infants. Fasting serum IRG levels in IHPS infants were not altered immediately by pyloromyotomy. The results from this study suggest a relationship between gastrin and idiopathic hypertrophic pyloric stenosis.
已测定确诊为特发性肥厚性幽门狭窄（IHPS）婴儿的血清免疫反应性胃泌素（IRG）水平，并与无IHPS的呕吐婴儿、正常婴儿及正常成年人的血清IRG水平进行比较。正常婴儿的平均血清IRG水平（103±9 pg/ml（平均值±标准误））超过正常成年人（28±5 pg/ml）。IHPS婴儿术前的平均血清IRG水平（256±26 pg/ml）显著高于正常婴儿和无IHPS的呕吐婴儿（93±9 pg/ml）。25%（5/20）的IHPS婴儿血清IRG水平处于正常婴儿的上限范围内。幽门肌切开术未立即改变IHPS婴儿的空腹血清IRG水平。本研究结果提示胃泌素与特发性肥厚性幽门狭窄之间存在关联。
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