Sancho David, Vicente-Manzanares Miguel, Mittelbrunn María, Montoya María C, Gordón-Alonso Mónica, Serrador Juan M, Sánchez-Madrid Francisco
Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Immunol Rev. 2002 Nov;189:84-97. doi: 10.1034/j.1600-065x.2002.18908.x.
The reorganization of membrane, cytoskeletal and signaling molecules during immune interactions is critical for the generation of immune response. At the initiation of the T cell-antigen presenting cell (APC) interaction, antigen-independent weak adhesion forces allow the scanning of the APC surface by the T cell receptor for specific antigens. The stabilization of T cell-APC conjugates involves the segregation of membrane and intracellular signaling proteins, driven by reorganization of membrane microdomains and cytoskeletal changes. In early T cell-APC cognate interactions, the microtubular cytoskeleton undergoes drastic changes that lead to microtubule-organizing center (MTOC) reorientation to the vicinity of the cell-cell contact area. Recent data on the dynamics of MTOC redistribution and its influence in T cell-APC conjugate stabilization, together with the description of an increasing number of signaling molecules associated to this complex, underscore the key role of MTOC translocation in the T cell response. We focus on the mechanisms that control the early MTOC reorientation during T cell-APC interaction and the relevance of this process to T cell activation.
免疫相互作用过程中膜、细胞骨架和信号分子的重组对于免疫反应的产生至关重要。在T细胞与抗原呈递细胞（APC）相互作用开始时，抗原非依赖性的弱粘附力使T细胞受体能够扫描APC表面以寻找特定抗原。T细胞与APC结合物的稳定涉及膜和细胞内信号蛋白的分离，这是由膜微结构域的重组和细胞骨架变化驱动的。在早期T细胞与APC的同源相互作用中，微管细胞骨架会发生剧烈变化，导致微管组织中心（MTOC）重新定位到细胞-细胞接触区域附近。关于MTOC重新分布的动力学及其对T细胞与APC结合物稳定的影响的最新数据，以及与该复合物相关的越来越多信号分子的描述，都强调了MTOC易位在T细胞反应中的关键作用。我们关注控制T细胞与APC相互作用过程中早期MTOC重新定位的机制以及该过程与T细胞活化的相关性。
