Grusell M, Widhe M, Ekerfelt C
Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
J Neuroimmunol. 2002 Oct;131(1-2):173-8. doi: 10.1016/s0165-5728(02)00255-2.
Lyme neuroborreliosis is a complex disease with different clinical outcomes and where immunopathological mechanisms are probably involved. In this study, sera and cerebrospinal fluid (CSF) from 21 neuroborreliosis patients and 26 control patients were analyzed for the Th1-inducing cytokines, interleukin (IL)-12 and IL-18, and the Th2 associated, soluble CD30 (sCD30) by ELISA. The results showed an increased number of neuroborreliosis patients expressing IL-12 (p<0.05) and IL-18 (p<0.05) in the CSF when compared with the controls, but no indication of increased levels in the sera. Nor were there any differences regarding levels of sCD30 in the sera or the CSF, indicating a local Th1-generating milieu in the target organ of neuroborreliosis.
莱姆病神经疏螺旋体病是一种具有不同临床结局的复杂疾病，可能涉及免疫病理机制。在本研究中，通过酶联免疫吸附测定法（ELISA）对21例神经疏螺旋体病患者和26例对照患者的血清和脑脊液（CSF）进行了分析，以检测诱导Th1的细胞因子白细胞介素（IL）-12和IL-18，以及与Th2相关的可溶性CD30（sCD30）。结果显示，与对照组相比，神经疏螺旋体病患者脑脊液中表达IL-12（p<0.05）和IL-18（p<0.05）的人数增加，但血清中无升高迹象。血清或脑脊液中sCD30水平也无差异，这表明神经疏螺旋体病靶器官中存在局部Th1产生环境。
