Clapp J F
Am J Obstet Gynecol. 1979 Jan 15;133(2):208-12. doi: 10.1016/0002-9378(79)90478-2.
Ten chronically instrumented pregnant ewes were studied to assess the effect of an epinephrine-induced decrease in uterine blood flow on the oxygen uptake of the uteroplacental-fetal tissue mass. Additional measurements of maternal cardiac output, oxygen uptake, arterial pressure, and hematocrit were obtained. Continuous systemic infusion of epinephrine at a rate of 0.3 to 0.4 microgram per kilogram per minute produced a mean decrease in uterine blood flow of 42 per cent (288 +/- 15 to 157 +/- 8 ml.per kilogram per minute). However, the oxygen uptake of the uteroplacental-fetal tissue mass remained at control levels due to an associated 79 per cent increase in the arteriovenous oxygen content difference across the uterine circulation. The calorigenic and cardiovascular systemic effects of epinephrine (a 22 per cent increase in maternal oxygen uptake and a 43 per cent increase in maternal cardiac output) were not related to the changes in either uterine flow or oxygen uptake. The implications of these observations are discussed.
对十只长期植入仪器的怀孕母羊进行了研究，以评估肾上腺素引起的子宫血流减少对子宫胎盘 - 胎儿组织团块氧摄取的影响。还获得了母体心输出量、氧摄取、动脉压和血细胞比容的额外测量值。以每分钟每千克0.3至0.4微克的速率持续全身输注肾上腺素，使子宫血流平均减少42%（从每分钟每千克288±15毫升降至157±8毫升）。然而，由于子宫循环中动静脉氧含量差相关地增加了79%，子宫胎盘 - 胎儿组织团块的氧摄取保持在对照水平。肾上腺素的产热和心血管系统效应（母体氧摄取增加22%，母体心输出量增加43%）与子宫血流或氧摄取的变化无关。讨论了这些观察结果的意义。
