Vercoutere Wenonah, Akeson Mark
National Space Grant Foundation, Bone/Signaling Laboratory, NASA Ames Research Center, Mail-Stop 236-7, Moffett Field, CA 94035, USA.
Curr Opin Chem Biol. 2002 Dec;6(6):816-22. doi: 10.1016/s1367-5931(02)00395-2.
DNA biosensors are being developed as alternatives to conventional DNA microarrays. These devices couple signal transduction directly to sequence recognition. Some of the most sensitive and functional technologies use fibre optics or electrochemical sensors in combination with DNA hybridization. In a shift from sequence recognition by hybridization, two emerging single-molecule techniques read sequence composition using zero-mode waveguides or electrical impedance in nanoscale pores.
DNA生物传感器正作为传统DNA微阵列的替代物而被研发。这些装置将信号转导直接与序列识别相结合。一些最灵敏且实用的技术将光纤或电化学传感器与DNA杂交结合使用。在从通过杂交进行序列识别的转变中，两种新兴的单分子技术利用零模式波导或纳米级孔隙中的电阻抗来读取序列组成。
