Hollis J B, Castell D O
J Appl Physiol. 1976 Jan;40(1):40-3. doi: 10.1152/jappl.1976.40.1.40.
The effects of cholinergic stimulation on esophageal peristalsis were studied in normal subjects. An intraesophageal transducer assembly was used to measure the dynamics of esophageal peristalsis before and after edrophonium chloride, 80 mug/kg intravenously. Following endrophonium, there was a marked increase in amplitude of esophageal persistalsis associated with a significant reduction in velocity of esophageal peristalsis and a significant increase in width and time of appearance of the contraction wave following a swallow. Graded doses of endrophonium all resulted in significant increases in peristaltic amplitude with the maximal response occurring at doses of 80 and 160 mug/kg. Similar results were obtained with a more direct-acting cholinergic agent, bethanechol, 80 mug/kg subcutaneously. The relevance of these results as an indication of the importance of cholinergic innervation in regulating esophageal motility are discussed.
在正常受试者中研究了胆碱能刺激对食管蠕动的影响。使用食管内换能器组件测量静脉注射80μg/kg氯化腾喜龙前后食管蠕动的动力学。注射腾喜龙后，食管蠕动幅度显著增加，同时食管蠕动速度显著降低，吞咽后收缩波的宽度和出现时间显著增加。不同剂量的腾喜龙均导致蠕动幅度显著增加，最大反应出现在80和160μg/kg剂量时。皮下注射80μg/kg更直接作用的胆碱能药物氨甲酰甲胆碱也得到了类似结果。讨论了这些结果作为胆碱能神经支配在调节食管运动中重要性指标的相关性。
