具有不同活性的噬菌体裂解酶组合对青霉素敏感和耐药肺炎链球菌菌株的协同致死作用。
Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains.
作者信息
Loeffler J M, Fischetti V A
机构信息
Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York, 10021, USA.
出版信息
Antimicrob Agents Chemother. 2003 Jan;47(1):375-7. doi: 10.1128/AAC.47.1.375-377.2003.
Abstract
Pal and Cpl-1, two purified bacteriophage lytic enzymes, were tested for their in vitro activity, alone and in combination, against several serotypes of Streptococcus pneumoniae, including penicillin-resistant strains. The enzymes demonstrated synergism in their ability to cleave the bacterial peptidoglycan and thus may be more efficient for the prevention and elimination of pneumococcal colonization.
摘要
帕尔（Pal）和Cpl-1这两种纯化的噬菌体裂解酶，分别单独以及联合测试了它们对包括耐青霉素菌株在内的几种肺炎链球菌血清型的体外活性。这些酶在裂解细菌肽聚糖的能力上表现出协同作用，因此在预防和消除肺炎球菌定植方面可能更有效。
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