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噬菌体裂解酶Cpl-1与青霉素或庆大霉素协同杀灭肺炎链球菌取决于青霉素耐药水平。

Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance.

作者信息

Djurkovic Svetolik, Loeffler Jutta M, Fischetti Vincent A

机构信息

Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.

出版信息

Antimicrob Agents Chemother. 2005 Mar;49(3):1225-8. doi: 10.1128/AAC.49.3.1225-1228.2005.

DOI:10.1128/AAC.49.3.1225-1228.2005
PMID:15728935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC549239/
Abstract

A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.

摘要

对噬菌体裂解酶Cpl-1与青霉素、庆大霉素、左氧氟沙星或阿奇霉素的组合，针对对青霉素有不同敏感性的肺炎链球菌菌株进行了测试。随着青霉素最低抑菌浓度（MIC）的降低，Cpl-1与庆大霉素的活性协同作用增强，而Cpl-1与青霉素对一株高度耐青霉素菌株显示出协同作用。

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本文引用的文献

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