Pavlov V A
Ural NII Phthisiopulmonology, Department of Health of RF, Ekaterinburg.
Probl Tuberk. 1997(3):48-51.
Guinea-pig experiments indicated that Mycobacteria tuberculosis (MBT) were actively involved in detoxification of the xenobiotics polycyclic aromatic hydrocarbons (PAH) and substantially altered the nonspecific protective mechanisms associated with activation of the body's antioxidative resources. MBT in the lung and liver tissues of animals long preexposed to PAH elevated the concentrations of sulphur-containing amino acids and glutathione with consumption of abundant nitrogen-rich adaptogenic antioxidants (arginine, urea) accumulated under the action of PAH. At the same time there is a upward trend for the body's antioxidative potentials both in a group infected with MBT and in group receiving PAH. Supplementing sodium glutamate potentiated the revealed adaptive rearrangements.
豚鼠实验表明，结核分枝杆菌（MBT）积极参与多环芳烃（PAH）等外源性物质的解毒过程，并显著改变了与机体抗氧化资源激活相关的非特异性保护机制。长期接触PAH的动物肺和肝组织中的MBT，在消耗PAH作用下积累的大量富含氮的适应原性抗氧化剂（精氨酸、尿素）的同时，提高了含硫氨基酸和谷胱甘肽的浓度。与此同时，感染MBT的组和接受PAH的组中机体的抗氧化潜能均呈上升趋势。补充谷氨酸可增强所揭示的适应性重排。
