Kenawy El Refaie, Layman John M, Watkins Jessica R, Bowlin Gary L, Matthews Jamil A, Simpson David G, Wnek Gary E
Department of Chemical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Biomaterials. 2003 Mar;24(6):907-13. doi: 10.1016/s0142-9612(02)00422-2.
Solutions of poly(ethylene-co-vinyl alcohol) or EVOH, ranging in composition from 56 to 71 wt% vinyl alcohol, can be readily electrospun at room temperature from solutions in 70% 2-propanol/water (rubbing alcohol). The solutions are prepared at 80 degrees C and allowed to cool to room temperature. Interestingly, the solutions are not stable at room temperature and eventually the polymer precipitates after several hours. However, prior to precipitation, electrospinning is extensive and rapid, allowing coverage of fibers on various substrates, including a grounded metal plate, dielectrics interposed between the charged jet and the metal ground, and on the human body. Fiber diameters of ca. 0.2-8.0 microm were obtained depending upon the solution concentration, an attractive range for tissue engineering, wound healing, and related applications. Electrospun EVOH mats have been shown to support the culturing of smooth muscle cells and fibroblasts.
乙烯 - 乙烯醇共聚物（EVOH）溶液，其乙烯醇含量在56至71 wt%之间，在室温下可轻松从70%异丙醇/水（外用酒精）溶液中进行静电纺丝。溶液在80摄氏度下制备，然后冷却至室温。有趣的是，这些溶液在室温下不稳定，最终聚合物会在数小时后沉淀。然而，在沉淀之前，静电纺丝过程广泛且迅速，能够在各种基材上形成纤维覆盖，包括接地金属板、置于带电射流与金属接地之间的电介质以及人体。根据溶液浓度，可获得直径约为0.2 - 8.0微米的纤维，这一范围对组织工程、伤口愈合及相关应用具有吸引力。已证明静电纺丝的EVOH垫可支持平滑肌细胞和成纤维细胞的培养。
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