Li R T H, Lai J S M, Ng J S K, Law R W K, Lau E M C, Lam D S C
Department of Ophthalmology, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong, People's Republic of China.
Br J Ophthalmol. 2003 Feb;87(2):157-9. doi: 10.1136/bjo.87.2.157.
BACKGROUND/AIMS: To determine whether topical 2% lignocaine (lidocaine) gel is an effective anaesthetic agent for chalazion surgery.
In a randomised controlled clinical trial, 57 subjects aged 12 years or over requiring incision and curettage for chalazion were recruited over an 8 month period. Patients were randomised into two groups. One group received 1.5 ml of lignocaine 2% injection and the other 1.5 ml of lignocaine 2% gel topically. Standard incision and curettage was then performed. The primary outcome of interest was the total pain experienced during the entire procedure including anaesthetic administration as well as incision and curettage. The pain from the local anaesthetic administration and during incision and curettage was assessed independently using a visual analogue scale (0-100). The sum of these two scores would be the total pain score out of 200. "Fear of injection" score (0-100) was also assessed.
There was a statistically significant difference in the mean total pain scores between the injection and the gel groups (95.6 v 57.0) (p <0.001) (alpha = 0.05) (1 - beta = 0.9394). There was a statistically significant difference in the mean scores on "pain of anaesthetic administration" (47.0 v 5.5) (p <0.000). There was no statistically significant differences in the mean scores on "fear of injection" (43.9 v 47.7) (p = 0.668) and "pain during incision and curettage" (48.28 v 51.4) (p=0.679).
Lignocaine 2% gel is effective in chalazion surgery especially in lowering the pain caused by anaesthetic administration.
背景/目的：确定局部使用2%利多卡因凝胶是否为睑板腺囊肿手术的有效麻醉剂。
在一项随机对照临床试验中，8个月内招募了57名12岁及以上需要进行睑板腺囊肿切开刮除术的受试者。患者被随机分为两组。一组接受1.5毫升2%利多卡因注射，另一组接受1.5毫升2%利多卡因凝胶局部给药。然后进行标准的切开刮除术。主要观察指标是整个手术过程中经历的总疼痛，包括麻醉给药以及切开和刮除过程。使用视觉模拟量表（0 - 100）独立评估局部麻醉给药时以及切开和刮除过程中的疼痛。这两个分数之和即为200分制的总疼痛评分。还评估了“注射恐惧”评分（0 - 100）。
注射组和凝胶组的平均总疼痛评分存在统计学显著差异（95.6对57.0）（p <0.001）（α = 0.05）（1 - β = 0.9394）。“麻醉给药疼痛”的平均评分存在统计学显著差异（47.0对5.5）（p <0.000）。“注射恐惧”的平均评分（43.9对47.7）（p = 0.668）和“切开和刮除过程中的疼痛”（48.28对51.4）（p = 0.679）没有统计学显著差异。
2%利多卡因凝胶在睑板腺囊肿手术中有效，尤其是在减轻麻醉给药引起的疼痛方面。
