Soffritti Morando, Belpoggi Fiorella, Lambertin Luca, Lauriola Michelina, Padovani Michela, Maltoni Cesare
Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy.
Ann N Y Acad Sci. 2002 Dec;982:87-105. doi: 10.1111/j.1749-6632.2002.tb04926.x.
Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was administered to 50 male and 50 female Sprague-Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L. Animals were kept under observation until spontaneous death. Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues.
从7周龄开始，向每组50只雄性和50只雌性斯普拉格-道利大鼠提供浓度分别为1500、1000、500、100、50、10或0毫克/升的饮用水，随意饮用，持续104周，让大鼠摄入甲醛。对照动物（100只雄性和100只雌性）仅饮用自来水。从6周龄开始，以2500、1500、500、250、50或0毫克/升的浓度，向50只雄性和50只雌性斯普拉格-道利大鼠给予乙醛。对动物进行观察直至自然死亡。结果发现，甲醛和乙醛会使治疗组的恶性肿瘤总数增加，并对各种器官和组织产生特定的致癌作用。
