Hjortland M C, McNamara P M, Kannel W B
Am J Epidemiol. 1976 Mar;103(3):304-11. doi: 10.1093/oxfordjournals.aje.a112228.
Longitudinal assessment of the effect of change in menopausal status on seven biologic concomitants was made in 40- to 51-year-old women from the cohort of 1686 women premenopausal at the initial Framingham examination and subsequently followed for nine biennial examinations. Within this age range, women of any specific age undergoing natural menopause were leaner at the exam prior to menopause than their controls; while women undergoing surgical menopause with bilateral oophorectomy were heavier. Hemoglobin levels rose after menopause. There was a rise in serum cholesterol levels between the premenopausal and menopausal examinations in natural menopause and in surgical menopause with bilateral oophorectomy. This rise was not seen in surgical menopause without bilateral oophorectomy. No significant changes in weight, blood pressure, blood glucose or vital capacity were found to accompany the menopause.
对1686名在最初的弗雷明汉检查时处于绝经前状态、随后接受了九次两年一次检查的40至51岁女性队列中的女性进行了纵向评估，以研究绝经状态变化对七种生物学伴随指标的影响。在这个年龄范围内，任何特定年龄自然绝经的女性在绝经前的检查中比其对照组更瘦；而接受双侧卵巢切除术进行手术绝经的女性则更重。绝经后血红蛋白水平升高。自然绝经以及双侧卵巢切除术后手术绝经的女性，绝经前和绝经后的检查之间血清胆固醇水平有所上升。在未进行双侧卵巢切除术的手术绝经中未观察到这种上升。未发现绝经伴随体重、血压、血糖或肺活量有显著变化。
