Iijima Ryosuke, Kisugi Jun, Yamazaki Masatoshi
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui-gun, Kanagawa, Japan.
Dev Comp Immunol. 2003 Apr;27(4):305-11. doi: 10.1016/s0145-305x(02)00105-2.
The sea hare Dolabella auricularia is a marine shell-less gastropod. Four cytotoxic glycoproteins named dolabellanin A, C, E and P were found in the animal previously. An antimicrobial factor was newly isolated from the sea hare's body-wall including skin and mucus. This factor is a novel peptide which consists of 33 amino acid residues, and is called dolabellanin B2. Dolabellanin B2 was cytotoxically effective against some pathogenic microorganisms at a concentration of 2.5-100 microg/ml.
海兔Dolabella auricularia是一种海洋无壳腹足纲动物。此前在该动物体内发现了四种细胞毒性糖蛋白，分别命名为海兔素A、C、E和P。从海兔包括皮肤和黏液的体壁中新分离出一种抗菌因子。该因子是一种由33个氨基酸残基组成的新型肽，被称为海兔素B2。海兔素B2在浓度为2.5 - 100微克/毫升时对一些致病微生物具有细胞毒性作用。
