Kisugi J, Kamiya H, Yamazaki M
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Dev Comp Immunol. 1989 Winter;13(1):3-8. doi: 10.1016/0145-305x(89)90010-4.
An antineoplastic factor, dolabellanin C, inducing tumor lysis was purified to apparent homogeneity from the body fluid of the sea hare Dollabella auricularia. Purified dolabellanin C is a glyco-protein of 215 K daltons containing 3 subunits of 70 K daltons. The amino acid sequence of the amino terminal region was also determined. This factor was active even at 0.38 ng protein/ml, but did not lyse normal white or red blood cells.
一种诱导肿瘤溶解的抗肿瘤因子——多拉贝兰宁C，从海兔耳状多拉贝螺的体液中纯化至表观同质。纯化后的多拉贝兰宁C是一种215千道尔顿的糖蛋白，含有3个70千道尔顿的亚基。还测定了氨基末端区域的氨基酸序列。该因子即使在0.38纳克蛋白质/毫升时仍具有活性，但不会裂解正常的白细胞或红细胞。
