生产减毒委内瑞拉马脑炎（TC - 83株）疫苗的改进方法。
Improved method for production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine.
作者信息
Cole F E, Pedersen C E, Robinson D M, Eddy G A
出版信息
J Clin Microbiol. 1976 Apr;3(4):460-2. doi: 10.1128/jcm.3.4.460-462.1976.
Abstract
Primary chicken embryo cell cultures were evaluated a s an alternate cell system for the production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine. The TC-83 strain virus was shown to remain stable during 10 serial passages in chicken embryo cell culture with regard to plaque size and morphology, virus yield, potency, and virulence for mice and hamsters.
摘要
原代鸡胚细胞培养物被评估为生产减毒委内瑞拉马脑炎（TC - 83株）疫苗的替代细胞系统。结果表明，TC - 83株病毒在鸡胚细胞培养中连续传代10次期间，在蚀斑大小和形态、病毒产量、效力以及对小鼠和仓鼠的毒力方面保持稳定。
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