Berglundh Tord, Donati Mauro, Hahn-Zoric Mirjana, Hanson Lars-A, Padyukov Leonid
Department of Periodontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
J Clin Periodontol. 2003 Mar;30(3):249-54. doi: 10.1034/j.1600-051x.2003.10274.x.
Severe forms of periodontitis are suggested to have a genetic basis.
The aim of the present investigation was to study association of an IL10 gene polymorphism (G to A transition at the -1087 position) with severe chronic periodontitis.
Two groups of Swedish Caucasian subjects were included. One group consisted of 60 patients (aged 36-74 years; mean 54.5+/-8.5) with severe and generalized chronic periodontitis. The patients exhibited bone loss >50% at all teeth. Thirty-nine periodontally healthy subjects between 35-78 years of age (mean 51.0+/-10.9) were also recruited. DNA was isolated from peripheral blood cells and genotyping was performed by combination of PCR with restriction endonuclease mapping.
The proportion of subjects that exhibited the GG genotype was significantly larger in the group with severe periodontitis than in the periodontally healthy group. The difference regarding the occurrence of the GG genotype between the two groups was more conspicuous in non-smokers and yielded an odds ratio of 6.1. The G allele carriage in non-smokers was >90 % in the periodontitis group and was significantly higher than in the healthy controls.
It is suggested that the -1087 IL10 polymorphism in Caucasian subjects of a north European origin is associated with severe chronic periodontitis.
重度牙周炎被认为具有遗传基础。
本研究旨在探讨白细胞介素10基因多态性（-1087位G到A的转换）与重度慢性牙周炎的关联。
纳入两组瑞典白种人受试者。一组由60例重度广泛性慢性牙周炎患者组成（年龄36 - 74岁；平均54.5±8.5岁）。这些患者所有牙齿的骨丧失均>50%。还招募了39名年龄在35 - 78岁之间（平均51.0±10.9岁）的牙周健康受试者。从外周血细胞中提取DNA，并通过聚合酶链反应与限制性内切酶图谱分析相结合的方法进行基因分型。
重度牙周炎组中表现出GG基因型的受试者比例显著高于牙周健康组。两组之间GG基因型出现频率的差异在非吸烟者中更为明显，优势比为6.1。牙周炎组非吸烟者中G等位基因携带率>90%，显著高于健康对照组。
提示北欧血统白种人中的-1087白细胞介素10多态性与重度慢性牙周炎相关。
