Piché Marie-Eve, Lapointe Annie, Weisnagel S John, Corneau Louise, Nadeau André, Bergeron Jean, Lemieux Simone
Institute of Nutraceuticals and Functional Foods, Laval University, Québec QC, Canada G1K 7P4.
Metabolism. 2008 Aug;57(8):1101-7. doi: 10.1016/j.metabol.2008.03.015.
The aim of the study was to examine how body fat distribution variables were associated with metabolic parameters in a sample of 113 postmenopausal women not receiving hormone therapy (56.9 +/- 4.4 years, 28.4 +/- 5.1 kg/m(2)). Body fat distribution variables (visceral adipose tissue [AT], subcutaneous AT, and total midthigh AT) were measured using computed tomography; body fat mass was assessed by hydrostatic weighing; insulin sensitivity was determined with the euglycemic-hyperinsulinemic clamp; fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) concentrations were measured by a 75-g oral glucose load; and (high-sensitivity) C-reactive protein (hs-CRP) was measured using a highly sensitive assay. After controlling for fat mass, visceral AT was positively associated with plasma triglyceride, hs-CRP, FPG, and 2hPG, and negatively associated with high-density lipoprotein cholesterol (HDL-C) and insulin sensitivity. Total midthigh AT was negatively associated with apolipoprotein B, FPG, and 2hPG, and positively associated with insulin sensitivity. Stepwise multiple regression analyses including abdominal visceral AT, subcutaneous AT and total midthigh AT as independent variables showed that abdominal visceral AT best predicted the variance in plasma triglyceride, HDL-C, low-density lipoprotein peak particle size, hs-CRP, FPG, 2hPG, and insulin sensitivity. Abdominal subcutaneous AT was a significant predictor of only insulin sensitivity, whereas total midthigh AT predicted HDL-C, low-density lipoprotein peak particle size, and apolipoprotein B. These multivariate analyses also indicated that total midthigh AT was favorably related to these outcomes, whereas abdominal visceral AT and subcutaneous AT were unfavorably related. These results confirmed that abdominal visceral fat is a critical correlate of metabolic parameters in postmenopausal women. In addition, a higher proportion of AT located in the total midthigh depot is associated with a favorable metabolic profile.
本研究旨在探讨在113名未接受激素治疗的绝经后女性样本（年龄56.9±4.4岁，体重指数28.4±5.1kg/m²）中，体脂分布变量与代谢参数之间的关联。采用计算机断层扫描测量体脂分布变量（内脏脂肪组织[AT]、皮下AT和大腿中部总AT）；通过水下称重评估体脂质量；用正常血糖-高胰岛素钳夹技术测定胰岛素敏感性；通过75g口服葡萄糖耐量试验测量空腹血糖（FPG）和2小时血糖（2hPG）浓度；使用高敏检测法测量（高敏）C反应蛋白（hs-CRP）。在控制了体脂质量后，内脏AT与血浆甘油三酯、hs-CRP、FPG和2hPG呈正相关，与高密度脂蛋白胆固醇（HDL-C）和胰岛素敏感性呈负相关。大腿中部总AT与载脂蛋白B、FPG和2hPG呈负相关，与胰岛素敏感性呈正相关。逐步多元回归分析将腹部内脏AT、皮下AT和大腿中部总AT作为自变量，结果显示腹部内脏AT最能预测血浆甘油三酯、HDL-C、低密度脂蛋白峰值粒径、hs-CRP、FPG、2hPG和胰岛素敏感性的变异。腹部皮下AT仅是胰岛素敏感性的显著预测因子，而大腿中部总AT可预测HDL-C、低密度脂蛋白峰值粒径和载脂蛋白B。这些多变量分析还表明，大腿中部总AT与这些结果呈有利相关，而腹部内脏AT和皮下AT与这些结果呈不利相关。这些结果证实，腹部内脏脂肪是绝经后女性代谢参数的关键相关因素。此外，位于大腿中部总脂肪库的AT比例较高与良好的代谢状况相关。
