Hertegård Stellan, Dahlqvist Ake, Laurent Claude, Borzacchiello Assunta, Ambrosio Luigi
Department of Logopedics and Phoniatrics, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Otolaryngol Head Neck Surg. 2003 Mar;128(3):401-6. doi: 10.1067/mhn.2003.96.
Vocal fold function is closely related to tissue viscoelasticity. Augmentation substances may alter the viscoelastic properties of vocal fold tissues and hence their vibratory capacity.
We sought to investigate the viscoelastic properties of rabbit vocal folds in vitro after injections of various augmentation substances.
Polytetrafluoroethylene (Teflon), cross-linked collagen (Zyplast), and cross-linked hyaluronan, hylan b gel (Hylaform) were injected into the lamina propria and the thyroarytenoid muscle of rabbit vocal folds. Dynamic viscosity of the injected vocal fold as a function of frequency was measured with a Bohlin parallel-plate rheometer during small-amplitude oscillation.
All injected vocal folds showed a decreasing dynamic viscosity with increasing frequency. Vocal fold samples injected with hylan b gel showed the lowest dynamic viscosity, quite close to noninjected control samples. Vocal folds injected with polytetrafluoroethylene showed the highest dynamic viscosity followed by the collagen samples.
The data indicated that hylan b gel in short-term renders the most natural viscoelastic properties to the vocal fold among the substances tested. This is of importance to restore/preserve the vibratory capacity of the vocal folds when glottal insufficiency is treated with injections.
声带功能与组织粘弹性密切相关。填充物质可能会改变声带组织的粘弹性，进而影响其振动能力。
我们旨在研究注射不同填充物质后兔声带在体外的粘弹性特性。
将聚四氟乙烯（特氟龙）、交联胶原蛋白（Zyplast）和交联透明质酸（hylan b凝胶，Hylaform）注射到兔声带的固有层和甲杓肌中。在小振幅振荡期间，使用Bohlin平行板流变仪测量注射后声带的动态粘度随频率的变化。
所有注射后的声带均表现出动态粘度随频率增加而降低。注射hylan b凝胶的声带样本动态粘度最低，与未注射的对照样本非常接近。注射聚四氟乙烯的声带动态粘度最高，其次是胶原蛋白样本。
数据表明，在所测试的物质中，hylan b凝胶在短期内能使声带具有最接近自然的粘弹性特性。当通过注射治疗声门功能不全时，这对于恢复/保留声带的振动能力非常重要。
