Borzacchiello A, Mayol L, Gärskog O, Dahlqvist A, Ambrosio L
Institute of Composite and Biomedical Materials, CNR and Interdisciplinary Research Center in Biomedical Materials (CRIB), University of Naples, Federico II, Piazzale Tecchio 80, 80125, Napoli, Italy.
J Mater Sci Mater Med. 2005 Jun;16(6):553-7. doi: 10.1007/s10856-005-0531-2.
The viscoelastic properties of vocal folds after injection of hyaluronic acid (hyaluronan, HA) based materials have been studied in an animal model (rabbit) six months after injection. The results indicate that the viscoelastic properties of the vocal folds injected with the HA based materials are similar to the healthy vocal folds (non-injected samples) used as control. Histological analysis has been also performed to investigate on the fate of the injected materials after six months from the implant. The HA based materials remain up to six months and they recruited fibroblasts that induce the ingrowth of new connective tissue resulting in an endogenous soft tissue augmentation. The HA based compounds are good candidate for further studies aimed at restoring/preserving the vibratory capacity of the vocal folds with injection treatment in glottal insufficiency.
在动物模型（兔子）中，对注射透明质酸（透明质烷，HA）基材料六个月后的声带粘弹性特性进行了研究。结果表明，注射了HA基材料的声带粘弹性特性与用作对照的健康声带（未注射样本）相似。还进行了组织学分析，以研究植入六个月后注射材料的转归。HA基材料可保留长达六个月，它们募集了成纤维细胞，诱导新结缔组织向内生长，从而实现内源性软组织增大。HA基化合物是进一步研究的良好候选物，这些研究旨在通过声门功能不全的注射治疗来恢复/保留声带的振动能力。
