Wan A K L, Seow W K, Purdie D M, Bird P S, Walsh L J, Tudehope D I
University of Queensland, School of Dentistry, Brisbane, Queensland, Australia.
Oral Microbiol Immunol. 2003 Apr;18(2):72-8. doi: 10.1034/j.1399-302x.2003.00044.x.
The aim of this longitudinal study was to determine salivary levels of total IgA, IgG and IgM in 84 preterm and 214 full-term infants, from birth to 18 months of age. Unstimulated whole saliva was collected from each infant at birth, and subsequently at 3-monthly intervals. Immunoglobulin levels were estimated using an ELISA technique. At birth, IgA was detected in 147/214 (69%) full-term infants but only 47/84 (56%) preterm infants (P < 0.01). In the case of IgG, 61% of full-term and 56% of preterm infants showed detectable levels, whereas IgM was found in 71% and 73%, respectively. Levels of IgA and IgG rose from birth to 18 months, whereas IgM levels did not change significantly. Increases in salivary levels of IgA were associated with introduction of solid foods (P < 0.001), as well as tooth eruption (P < 0.001). Our results indicate that the majority of full-term and preterm infants are orally immunocompetent at birth.
这项纵向研究的目的是测定84名早产儿和214名足月儿从出生到18个月大时唾液中总IgA、IgG和IgM的水平。在出生时以及随后每隔3个月从每个婴儿采集未刺激的全唾液。使用酶联免疫吸附测定（ELISA）技术估算免疫球蛋白水平。出生时，147/214（69%）的足月儿检测到IgA，但只有47/84（56%）的早产儿检测到IgA（P<0.01）。就IgG而言，61%的足月儿和56%的早产儿显示出可检测水平，而IgM分别在71%和73%的婴儿中被发现。IgA和IgG的水平从出生到18个月有所上升，而IgM水平没有显著变化。唾液中IgA水平的升高与固体食物的引入（P<0.001）以及牙齿萌出（P<0.001）有关。我们的结果表明，大多数足月儿和早产儿在出生时口腔具有免疫能力。
