万古霉素治疗失败与异质性万古霉素中介金黄色葡萄球菌相关，见于一名患有心内膜炎的患者以及心内膜炎兔模型。
Vancomycin treatment failure associated with heterogeneous vancomycin-intermediate Staphylococcus aureus in a patient with endocarditis and in the rabbit model of endocarditis.
作者信息
Moore Matthew R, Perdreau-Remington Françoise, Chambers Henry F
机构信息
Division of Infectious Diseases, San Francisco General Hospital, California, USA.
出版信息
Antimicrob Agents Chemother. 2003 Apr;47(4):1262-6. doi: 10.1128/AAC.47.4.1262-1266.2003.
Abstract
Heterogeneous resistance to vancomycin is thought to precede emergence of intermediate susceptibility to vancomycin in Staphylococcus aureus, but the clinical significance of heterogeneous resistance is unknown. Paired S. aureus isolates from a patient with endocarditis who relapsed after vancomycin treatment were tested for heterogeneous resistance to vancomycin. The pretreatment and the relapse clinical isolates (strains SF1 and SF2, respectively) were genotyped by pulsed-field gel electrophoresis. Susceptibility to vancomycin was assessed by the broth dilution method, population analysis, and time-kill studies and in the rabbit model of endocarditis. Strains SF1 and SF2 had similar genotypes, and the vancomycin MICs for the strains were </=2 micro g/ml. SF2 exhibited heterogeneous resistance to vancomycin. Vancomycin eradicated SF1 in the rabbit model of endocarditis, while SF2 persisted at pretreatment levels. Vancomycin treatment failure in this patient with endocarditis was attributable to heterogeneous resistance to vancomycin.
摘要
在金黄色葡萄球菌中，对万古霉素的异质性耐药被认为先于对万古霉素中介敏感性的出现，但异质性耐药的临床意义尚不清楚。对一名患有心内膜炎的患者在万古霉素治疗后复发的成对金黄色葡萄球菌分离株进行了对万古霉素异质性耐药的检测。通过脉冲场凝胶电泳对治疗前和复发时的临床分离株（分别为菌株SF1和SF2）进行基因分型。通过肉汤稀释法、群体分析、时间杀菌研究以及在心内膜炎兔模型中评估对万古霉素的敏感性。菌株SF1和SF2具有相似的基因型，且这些菌株的万古霉素最低抑菌浓度≤2μg/ml。SF2表现出对万古霉素的异质性耐药。在兔心内膜炎模型中，万古霉素根除了SF1，而SF2维持在治疗前水平。该心内膜炎患者万古霉素治疗失败归因于对万古霉素的异质性耐药。
相似文献
1
Vancomycin treatment failure associated with heterogeneous vancomycin-intermediate Staphylococcus aureus in a patient with endocarditis and in the rabbit model of endocarditis.万古霉素治疗失败与异质性万古霉素中介金黄色葡萄球菌相关，见于一名患有心内膜炎的患者以及心内膜炎兔模型。
Antimicrob Agents Chemother. 2003 Apr;47(4):1262-6. doi: 10.1128/AAC.47.4.1262-1266.2003.
2
Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.头孢比普在耐甲氧西林和万古霉素中介金黄色葡萄球菌所致兔主动脉瓣心内膜炎模型中的评价。
Antimicrob Agents Chemother. 2005 Mar;49(3):884-8. doi: 10.1128/AAC.49.3.884-888.2005.
3
Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureus.替考拉宁在耐甲氧西林金黄色葡萄球菌或万古霉素中介金黄色葡萄球菌所致兔主动脉瓣心内膜炎模型中的疗效
Antimicrob Agents Chemother. 2005 Aug;49(8):3163-5. doi: 10.1128/AAC.49.8.3163-3165.2005.
4
In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model.在兔心内膜炎模型中，新型广谱头孢菌素头孢洛林（PPI-0903）与利奈唑胺和万古霉素相比，对耐甲氧西林和万古霉素中介金黄色葡萄球菌的体内疗效。
Antimicrob Agents Chemother. 2007 Sep;51(9):3397-400. doi: 10.1128/AAC.01242-06. Epub 2007 Jun 25.
5
Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin.由对万古霉素敏感性降低的金黄色葡萄球菌引起的感染性心内膜炎。
Clin Infect Dis. 2004 Apr 15;38(8):1188-91. doi: 10.1086/383027. Epub 2004 Apr 5.
6
Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group.金黄色葡萄球菌中万古霉素耐药性的出现。糖肽类中介金黄色葡萄球菌工作组。
N Engl J Med. 1999 Feb 18;340(7):493-501. doi: 10.1056/NEJM199902183400701.
7
Ciprofloxacin versus vancomycin in the therapy of experimental methicillin-resistant Staphylococcus aureus endocarditis.环丙沙星与万古霉素治疗实验性耐甲氧西林金黄色葡萄球菌心内膜炎的比较
Antimicrob Agents Chemother. 1987 Apr;31(4):527-30. doi: 10.1128/AAC.31.4.527.
8
Vancomycin-intermediate Staphylococcus aureus selected during vancomycin therapy of experimental endocarditis are not detected by culture-based diagnostic procedures and persist after treatment arrest.万古霉素治疗实验性心内膜炎期间选择的中间葡萄球菌耐万古霉素，但不能通过基于培养的诊断程序检测到，并且在治疗停止后仍持续存在。
J Antimicrob Chemother. 2012 Mar;67(3):652-60. doi: 10.1093/jac/dkr521. Epub 2011 Dec 13.
9
Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin.万古霉素与β-内酰胺类药物联合使用对万古霉素敏感性降低的葡萄球菌具有协同作用。
Antimicrob Agents Chemother. 1999 Jul;43(7):1747-53. doi: 10.1128/AAC.43.7.1747.
10
Development of resistance to fleroxacin during therapy of experimental methicillin-susceptible Staphylococcus aureus endocarditis.实验性甲氧西林敏感金黄色葡萄球菌心内膜炎治疗期间对氟罗沙星耐药性的产生
Antimicrob Agents Chemother. 1991 Aug;35(8):1547-50. doi: 10.1128/AAC.35.8.1547.
引用本文的文献
1
Droplet microfluidics-based detection of rare antibiotic-resistant subpopulations in from bloodstream infections.基于微滴微流控技术检测血流感染中罕见的抗生素耐药亚群。
Sci Adv. 2025 Jul 4;11(27):eadv4558. doi: 10.1126/sciadv.adv4558.
2
Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance.细菌异质性耐药的流行病学、机制及临床影响
NPJ Antimicrob Resist. 2025 Jan 28;3(1):7. doi: 10.1038/s44259-025-00076-5.
3
Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study.瑞典乌普萨拉患者大肠埃希菌血流感染中异质性耐药表型的患病率、错误分类及临床后果：一项回顾性队列研究
Lancet Microbe. 2025 Apr;6(4):101010. doi: 10.1016/j.lanmic.2024.101010. Epub 2025 Jan 16.
4
Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance.三种并发机制导致基因拷贝数变异和短暂抗生素异质性耐药。
Nat Commun. 2024 May 10;15(1):3981. doi: 10.1038/s41467-024-48233-0.
5
Update on bacterial pathogens: virulence and resistance.细菌病原体的最新情况：毒力与耐药性
Enferm Infecc Microbiol Clin. 2008 Apr;26:3-21. doi: 10.1016/S0213-005X(08)76378-X. Epub 2009 May 13.
6
High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes.金黄色葡萄球菌异质性耐药的高发生率是由核心基因的多种突变引起的。
PLoS Biol. 2024 Jan 4;22(1):e3002457. doi: 10.1371/journal.pbio.3002457. eCollection 2024 Jan.
7
Rapid Detection of Clarithromycin and Amikacin Resistance in Mycobacterium abscessus Complex by High-Resolution Melting Curve Analysis.高分辨率熔解曲线分析快速检测脓肿分枝杆菌复合体中克拉霉素和阿米卡星耐药性
Microbiol Spectr. 2022 Jun 29;10(3):e0057422. doi: 10.1128/spectrum.00574-22. Epub 2022 May 31.
8
Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL/AmpC-Producing Clinical Isolates on Antibiotic Treatment in Experimentally Infected Mice.产超广谱β-内酰胺酶/头孢菌素酶的多重耐药临床分离株中碳青霉烯类异质性耐药对实验性感染小鼠抗生素治疗的影响
Infect Drug Resist. 2021 Dec 23;14:5639-5650. doi: 10.2147/IDR.S340652. eCollection 2021.
9
The highly dynamic nature of bacterial heteroresistance impairs its clinical detection.细菌异质性耐药的高度动态特性使其临床检测变得困难。
Commun Biol. 2021 May 5;4(1):521. doi: 10.1038/s42003-021-02052-x.
10
Antibiotic resistance and persistence-Implications for human health and treatment perspectives.抗生素耐药性和持久性-对人类健康的影响和治疗观点。
EMBO Rep. 2020 Dec 3;21(12):e51034. doi: 10.15252/embr.202051034. Epub 2020 Dec 8.
本文引用的文献
1
Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco.旧金山城市贫困人口中耐甲氧西林金黄色葡萄球菌的基于人群的社区患病率。
Clin Infect Dis. 2002 Feb 15;34(4):425-33. doi: 10.1086/338069. Epub 2002 Jan 2.
2
Community-acquired methicillin-resistant Staphylococcus aureus infections in south Texas children.
Pediatr Infect Dis J. 2001 Sep;20(9):860-3. doi: 10.1097/00006454-200109000-00007.
3
Epidemiology and clonality of community-acquired methicillin-resistant Staphylococcus aureus in Minnesota, 1996-1998.1996 - 1998年明尼苏达州社区获得性耐甲氧西林金黄色葡萄球菌的流行病学及克隆性研究
Clin Infect Dis. 2001 Oct 1;33(7):990-6. doi: 10.1086/322693. Epub 2001 Sep 5.
4
Vancomycin-resistant Staphylococcus aureus occurs in South Africa.耐万古霉素金黄色葡萄球菌在南非出现。
S Afr Med J. 2000 Nov;90(11):1113.
5
Vancomycin-intermediate Staphylococcus aureus in Korea.韩国的万古霉素中介金黄色葡萄球菌。
J Clin Microbiol. 2000 Oct;38(10):3879-81. doi: 10.1128/JCM.38.10.3879-3881.2000.
6
Lysostaphin treatment of experimental aortic valve endocarditis caused by a Staphylococcus aureus isolate with reduced susceptibility to vancomycin.用溶葡萄球菌素治疗由一株对万古霉素敏感性降低的金黄色葡萄球菌分离株引起的实验性主动脉瓣心内膜炎。
Antimicrob Agents Chemother. 1999 Jul;43(7):1754-5. doi: 10.1128/AAC.43.7.1754.
7
Staphylococcus aureus with reduced susceptibility to vancomycin isolated from a patient with fatal bacteremia.从一名患有致命菌血症的患者身上分离出的对万古霉素敏感性降低的金黄色葡萄球菌。
Emerg Infect Dis. 1999 Jan-Feb;5(1):147-9. doi: 10.3201/eid0501.990118.
8
Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group.利福平在治疗骨科植入物相关葡萄球菌感染中的作用：一项随机对照试验。异物感染（FBI）研究组。
JAMA. 1998 May 20;279(19):1537-41. doi: 10.1001/jama.279.19.1537.
9
Characterization of staphylococci with reduced susceptibilities to vancomycin and other glycopeptides.对万古霉素及其他糖肽类抗生素敏感性降低的葡萄球菌的特性研究
J Clin Microbiol. 1998 Apr;36(4):1020-7. doi: 10.1128/JCM.36.4.1020-1027.1998.
10
Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin.耐万古霉素异质性金黄色葡萄球菌菌株在日本医院的传播。
Lancet. 1997 Dec 6;350(9092):1670-3. doi: 10.1016/S0140-6736(97)07324-8.
Zotero 插件