Moises-Alfaro Celia, Berrón-Pérez Renato, Carrasco-Daza Daniel, Gutiérrez-Castrellón Pedro, Ruiz-Maldonado Ramón
Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico.
Pediatr Dermatol. 2003 Mar-Apr;20(2):103-7. doi: 10.1046/j.1525-1470.2003.20201.x.
Among 27 pediatric patients with a clinicopathologic diagnosis of discoid lupus erythematosus (DLE), 15 had localized cutaneous lesions and 12 had disseminated lesions. During a mean follow-up period of 36 months, seven patients (26%) developed systemic lupus erythematosus (SLE). Four of these patients were less than 10 years of age. No correlation was found between localized and disseminated lesions and evolution to SLE. Three of four patients with a positive family history for rheumatoid disease developed SLE (p < 0.05). Hyperpigmentation was significantly more frequent (p < 0.04) in children less than 10 years of age. There was a female predominance of 5:1 among patients less than 10 years of age. Our findings suggest that onset of DLE prior to 10 years of age does not indicate a greater risk of developing SLE. The occurrence of localized or disseminated lesions does not seem to influence the outcome.
在27例经临床病理诊断为盘状红斑狼疮（DLE）的儿科患者中，15例有局限性皮肤损害，12例有播散性损害。在平均36个月的随访期内，7例患者（26%）发展为系统性红斑狼疮（SLE）。其中4例患者年龄小于10岁。局限性和播散性损害与发展为SLE之间未发现相关性。类风湿病家族史阳性的4例患者中有3例发展为SLE（p<0.05）。色素沉着在10岁以下儿童中明显更常见（p<0.04）。10岁以下患者中女性占比为5:1。我们的研究结果表明，10岁之前发生DLE并不表明发生SLE的风险更高。局限性或播散性损害的出现似乎不影响预后。
