Millichap J Gordon, Yee Michelle M
Division of Neurology, Children's Memorial Hospital, Chicago, Illinois 60614, USA.
Pediatr Neurol. 2003 Jan;28(1):9-15. doi: 10.1016/s0887-8994(02)00466-6.
Diet can play an important role in the precipitation of headaches in children and adolescents with migraine. The diet factor in pediatric migraine is frequently neglected in favor of preventive drug therapy. The list of foods, beverages, and additives that trigger migraine includes cheese, chocolate, citrus fruits, hot dogs, monosodium glutamate, aspartame, fatty foods, ice cream, caffeine withdrawal, and alcoholic drinks, especially red wine and beer. Underage drinking is a significant potential cause of recurrent headache in today's adolescent patients. Tyramine, phenylethylamine, histamine, nitrites, and sulfites are involved in the mechanism of food intolerance headache. Immunoglobulin E-mediated food allergy is an infrequent cause. Dietary triggers affect phases of the migraine process by influencing release of serotonin and norepinephrine, causing vasoconstriction or vasodilatation, or by direct stimulation of trigeminal ganglia, brainstem, and cortical neuronal pathways. Treatment begins with a headache and diet diary and the selective avoidance of foods presumed to trigger attacks. A universal migraine diet with simultaneous elimination of all potential food triggers is generally not advised in practice. A well-balanced diet is encouraged, with avoidance of fasting or skipped meals. Long-term prophylactic drug therapy is appropriate only after exclusion of headache-precipitating trigger factors, including dietary factors.
饮食在偏头痛患儿及青少年头痛发作中可能起重要作用。小儿偏头痛的饮食因素常被忽视,而更倾向于预防性药物治疗。引发偏头痛的食物、饮料和添加剂包括奶酪、巧克力、柑橘类水果、热狗、味精、阿斯巴甜、高脂肪食物、冰淇淋、咖啡因戒断反应以及酒精饮料,尤其是红酒和啤酒。未成年人饮酒是当今青少年患者反复头痛的一个重要潜在原因。酪胺、苯乙胺、组胺、亚硝酸盐和亚硫酸盐与食物不耐受性头痛的机制有关。免疫球蛋白E介导的食物过敏是一个不常见的原因。饮食诱因通过影响血清素和去甲肾上腺素的释放、引起血管收缩或扩张,或直接刺激三叉神经节、脑干和皮质神经元通路,从而影响偏头痛过程的各个阶段。治疗始于头痛和饮食日记,并选择性地避免食用被认为会引发发作的食物。实际上,一般不建议采用同时排除所有潜在食物诱因的通用偏头痛饮食。鼓励均衡饮食,避免禁食或不按时进餐。只有在排除包括饮食因素在内的头痛诱发因素后,长期预防性药物治疗才是合适的。