单纯疱疹病毒野生型及膦甲酸抗性突变体的脱氧核糖核酸聚合酶
Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.
作者信息
Fridlender B, Chejanovsky N, Becker Y
出版信息
Antimicrob Agents Chemother. 1978 Jan;13(1):124-7. doi: 10.1128/AAC.13.1.124.
Abstract
The phosphonacetic acid (PAA)-susceptible deoxyribonucleic acid (DNA) polymerase of herpes simplex virus type 1 was partially purified and isolated in sucrose gradients and on double-strand DNA cellulose columns. The DNA polymerase isolated from cells infected with the PAA-resistant mutant had the same molecular weight as the wild-type enzyme (140,000 to 149,000) but was consistently more resistant to PAA.
摘要
单纯疱疹病毒1型对膦甲酸钠（PAA）敏感的脱氧核糖核酸（DNA）聚合酶在蔗糖梯度和双链DNA纤维素柱上进行了部分纯化和分离。从感染了PAA抗性突变体的细胞中分离出的DNA聚合酶与野生型酶具有相同的分子量（140,000至149,000），但对PAA的抗性始终更强。
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