万古霉素与青霉素及头孢菌素对铜绿假单胞菌、克雷伯菌和沙雷菌的协同作用。
Synergy of vancomycin with penicillins and cephalosporins against pseudomonas, klebsiella, and serratia.
作者信息
Donabedian H, Andriole V T
出版信息
Yale J Biol Med. 1977 Mar-Apr;50(2):165-76.
A model of antibiotic synergy based on a molecular mechanism of action which blocked sequential steps in a single metabolic pathway was tested. Twenty-five strains each of Pseudomonas, Klebsiella, and Serratia were tested in vitro against three different two drug combinations of vancomycin, carbenicillin, or cephalothin. Synergy was observed when vancomycin was combined with either carbenicillin or cephalothin against isolates of Pseudomonas or Serratia, whereas the combination of carbenicillin and cephalothin did not result in significant synergy against these isolates. The presence of synergy was not related to the sensitivity or resistance of the isolates to the drugs in the combination. Synergy was also observed with all three antibiotic combinations against Klebsiella isolates which may be related to enzyme inactivation by one of the drugs in the combination. These observations support the hypothetical model of antibiotic synergy based on sequential blocking of one biochemical pathway.
基于作用分子机制的抗生素协同作用模型进行了测试，该机制阻断单一代谢途径中的连续步骤。对25株铜绿假单胞菌、克雷伯菌和沙雷菌，针对三种不同的万古霉素、羧苄西林或头孢噻吩两种药物组合进行体外测试。当万古霉素与羧苄西林或头孢噻吩联合用于铜绿假单胞菌或沙雷菌分离株时观察到协同作用，而羧苄西林和头孢噻吩组合对这些分离株未产生显著协同作用。协同作用的存在与分离株对组合中药物的敏感性或耐药性无关。针对克雷伯菌分离株的所有三种抗生素组合也观察到协同作用，这可能与组合中一种药物的酶失活有关。这些观察结果支持基于对一条生化途径的顺序阻断的抗生素协同作用假说模型。
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