Weisbrot David, Lin Hana, Ye Lin, Blank Martin, Goodman Reba
Department of Pathology, Columbia University Health Sciences, 630 West 168 St. NYC, New York 10032, USA.
J Cell Biochem. 2003 May 1;89(1):48-55. doi: 10.1002/jcb.10480.
In this report we examined the effects of a discontinuous radio frequency (RF) signal produced by a GSM multiband mobile phone (900/1,900 MHz; SAR approximately 1.4 W/kg) on Drosophila melanogaster, during the 10-day developmental period from egg laying through pupation. As found earlier with low frequency exposures, the non-thermal radiation from the GSM mobile phone increased numbers of offspring, elevated hsp70 levels, increased serum response element (SRE) DNA-binding and induced the phosphorylation of the nuclear transcription factor, ELK-1. The rapid induction of hsp70 within minutes, by a non-thermal stress, together with identified components of signal transduction pathways, provide sensitive and reliable biomarkers that could serve as the basis for realistic mobile phone safety guidelines.
在本报告中，我们研究了GSM多频段移动电话（900/1900兆赫；比吸收率约为1.4瓦/千克）产生的间断射频（RF）信号，在从产卵到化蛹的10天发育期内对黑腹果蝇的影响。正如早期低频暴露研究中所发现的那样，GSM移动电话发出的非热辐射增加了后代数量，提高了热休克蛋白70（hsp70）水平，增强了血清反应元件（SRE）与DNA的结合，并诱导了核转录因子ELK-1的磷酸化。非热应激在数分钟内快速诱导hsp70，以及已确定的信号转导通路组成部分，提供了敏感且可靠的生物标志物，可为切实可行的移动电话安全指南奠定基础。
