Hu Yingqing, Wang Zhongjun, Song Yueying, Deng Changhu
Medical College of Chinese People's Armed Police Forces, Tianjin, 300162.
Zhong Yao Cai. 2002 Dec;25(12):893-5.
To study the effects of rhubarb extract by the technology free of heating (RETFH) and the extracts from crude rhubarb and from prepared rhubarb on intestine movement and analgesia in mice, and to compare the effects each other.
Intestine movement was studied by determining the distance in intestine after administrating the extracts from different technology with ink as indicator. Analgesia effect was studied by hot plate test and torsion test induced by acetic acid for the extracts from different technology.
Diarrhea effect of low dose (0.75 mg/g) RETFH was moderate, and equal to that of high dose (3.00 mg/g) extract from prepared rhubarb. Remarkable analgesia effect of low dose (0.50 mg/g) RETFH was equal to that of middle and high dose (2.00 mg/g, 4.00 mg/g) extracts from prepared rhubarb and high dose (4.00 mg/g) extract from crude rhubarb.
0.50 mg/g RETFH possessed obvious diarrhea and analgesia effects. To utilize the technology free of heating may decrease dosage of rhubarb and save medicinal resource.
研究采用无加热技术制备的大黄提取物（RETFH）、生大黄提取物及熟大黄提取物对小鼠肠运动及镇痛的影响，并进行相互比较。
以墨汁为指标，通过测定不同工艺提取物给药后肠内移动距离研究肠运动。采用热板法和醋酸扭体法研究不同工艺提取物的镇痛作用。
低剂量（0.75mg/g）RETFH的致泻作用中等，与高剂量（3.00mg/g）熟大黄提取物相当。低剂量（0.50mg/g）RETFH有显著的镇痛作用，与中、高剂量（2.00mg/g、4.00mg/g）熟大黄提取物及高剂量（4.00mg/g）生大黄提取物相当。
0.50mg/g RETFH具有明显的致泻和镇痛作用。采用无加热技术可降低大黄用量，节约药材资源。
