十二指肠溃疡患者在迷走神经干切断术前、后，空肠对十二指肠内高渗葡萄糖诱导的胃酸分泌的抑制作用。
Jejunal inhibition of gastric acid secretion induced by hypertonic glucose in duodenal ulcer patients before and after truncal vagotomy.
作者信息
Christiansen J, Aagaard P, Hansen T
出版信息
Ann Surg. 1978 Feb;187(2):122-5. doi: 10.1097/00000658-197802000-00004.
The effect of intrajejunal infusion of hypertonic glucose on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in eight duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 44.0 +/- 3.1 meq H+/hr to 29.2 +/- 2.9 meq H+/hr (p less than 0.05), whereas no consistent changes were found postoperatively, suggesting that jejunal inhibition of gastric acid secretion induced by hypertonic glucose primarily is under vegal control. Furthermore, the study shows that glucose induced jejunal inhibition of acid secretion seems to be less pronouced in duodenal ulcer patients than previously found in healthy subjects.
在八名十二指肠溃疡患者中，研究了空肠内输注高渗葡萄糖对五肽胃泌素刺激（0.5微克/千克·小时）胃酸分泌的影响，观察时间为迷走神经干切断术前及术后三至五个月。术前平均胃酸分泌量从44.0±3.1毫当量氢离子/小时降至29.2±2.9毫当量氢离子/小时（p<0.05），而术后未发现一致的变化，这表明高渗葡萄糖诱导的空肠对胃酸分泌的抑制主要受迷走神经控制。此外，该研究表明，葡萄糖诱导的空肠对胃酸分泌的抑制在十二指肠溃疡患者中似乎不如先前在健康受试者中发现的那样明显。
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