Scholey Jonathan M, Brust-Mascher Ingrid, Mogilner Alex
Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, California 95616, USA.
Nature. 2003 Apr 17;422(6933):746-52. doi: 10.1038/nature01599.
In creating the mitotic spindle and the contractile ring, natural selection has engineered fascinating precision machines whose movements depend upon forces generated by ensembles of cytoskeletal proteins. These machines segregate chromosomes and divide the cell with high fidelity. Current research on the mechanisms and regulation of spindle morphogenesis, chromosome motility and cytokinesis emphasizes how ensembles of dynamic cytoskeletal polymers and multiple motors cooperate to generate the forces that guide the cell through mitosis and cytokinesis.
在构建有丝分裂纺锤体和收缩环的过程中，自然选择塑造了令人着迷的精密机器，其运动依赖于细胞骨架蛋白集合体产生的力。这些机器能高保真地分离染色体并分裂细胞。当前关于纺锤体形态发生、染色体运动和胞质分裂的机制及调控的研究，着重关注动态细胞骨架聚合物集合体与多种马达蛋白如何协同作用，以产生引导细胞完成有丝分裂和胞质分裂的力。
