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针对变形链球菌BHT的细胞内和细胞外脂磷壁酸形成交叉反应抗体。

Formation of cross-reacting antibodies against cellular and extracellular lipoteichoic acid of Streptococcus mutans BHT.

作者信息

Knox K W, Markham J L, Wicken A J

出版信息

Infect Immun. 1976 Mar;13(3):647-52. doi: 10.1128/iai.13.3.647-652.1976.

Abstract

Antisera prepared against strains of Streptococcus mutans, particularly strain BHT, contain antibodies to the membrane lipoteichoic acid component that will cross-react with lipoteichoic acids from three species of lactobacilli. A more detailed study of the antibodies to strain BHT confirmed that the antibodies are specific for the polyglycerol phosphate component common to the lipoteichoic acids. Sera with a higher hemagglutinating titer could be obtained by injecting disrupted organisms. The partially purified lipoteichoic acid isolated from the culture fluid of S. mutans BHT was also immunogenic antibodies; antibodies were also formed against another unidentified component in this extracellular fraction.

摘要

针对变形链球菌菌株,特别是BHT菌株制备的抗血清,含有针对膜脂磷壁酸成分的抗体,这些抗体将与三种乳酸杆菌的脂磷壁酸发生交叉反应。对BHT菌株抗体的更详细研究证实,这些抗体对脂磷壁酸共有的聚甘油磷酸成分具有特异性。通过注射破碎的生物体可以获得血凝滴度更高的血清。从变形链球菌BHT培养液中分离出的部分纯化脂磷壁酸也是免疫原性抗体;还形成了针对该细胞外部分中另一种未鉴定成分的抗体。

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本文引用的文献

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Antigens of Streptococcus sanguis.血链球菌抗原。
Infect Immun. 1973 Feb;7(2):205-11. doi: 10.1128/iai.7.2.205-211.1973.
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Immunological properties of teichoic acids.磷壁酸的免疫学特性。
Bacteriol Rev. 1973 Jun;37(2):215-57. doi: 10.1128/br.37.2.215-257.1973.

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