Cerklewski F L, Forbes R M
J Nutr. 1977 Jan;107(1):143-6. doi: 10.1093/jn/107.1.143.
An investigation of the influence of dietary copper (1, 5, 20 ppm) on toxicity of dietary lead (0 and 200 ppm) in the young male rat in a 4-week period indicated that as dietary copper increase so did the severity of lead toxicity. Evidence included increased lead concentration in kidney and a two- to threefold increase in the excretion of urinary delta-aminolevulinic acid. Liver copper concentration was also found to increase in rats receiving lead at the two lower copper levels. The data suggest that supplementary dietary copper doesnot lessen the severity of lead toxicity but rather exaggerates it.
一项关于膳食铜（1、5、20 ppm）对幼龄雄性大鼠膳食铅（0和200 ppm）毒性在4周内影响的研究表明，随着膳食铜含量增加，铅毒性的严重程度也随之增加。证据包括肾脏中铅浓度升高以及尿δ-氨基乙酰丙酸排泄量增加两到三倍。还发现，在较低的两个铜水平下接受铅的大鼠肝脏铜浓度也有所增加。数据表明，膳食补充铜不会减轻铅毒性的严重程度，反而会使其加剧。
