粟酒裂殖酵母中抗抑制突变体的遗传分析。
Genetic analysis of antisuppressor mutants in the fission yeast Schizosaccharomyces pombe.
作者信息
Thuriaux P, Minet M, Hofer F, Leupold U
出版信息
Mol Gen Genet. 1976 Dec 31;142(4):251-61. doi: 10.1007/BF00271250.
PMID:1272244
Abstract
Fourteen unlinked sin genes could be mutated to recessive antisuppressor alleles preventing the expression of suppressors in the fission yeast Schizosaccharomyces pombe. cyh1 alleles, resistant to the ribosomal inhibitor cycloheximide, also have some antisuppressor effect. The genetical and physiological characterization of these mutants is consistent with the hypothesis that they affect components of the messenger RNA translation machinery such as tRNA modifying enzymes or ribosomal proteins.
摘要
在裂殖酵母粟酒裂殖酵母中，14个不连锁的sin基因可突变为隐性抗抑制等位基因，从而阻止抑制子的表达。对核糖体抑制剂环己酰亚胺具有抗性的cyh1等位基因也具有一定的抗抑制作用。这些突变体的遗传学和生理学特征与它们影响信使RNA翻译机制的组成部分（如tRNA修饰酶或核糖体蛋白）这一假设相一致。
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