穿心莲的免疫刺激剂

Immunostimulant agents from Andrographis paniculata.

作者信息

Puri A, Saxena R, Saxena R P, Saxena K C, Srivastava V, Tandon J S

机构信息

Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

出版信息

J Nat Prod. 1993 Jul;56(7):995-9. doi: 10.1021/np50097a002.

DOI:10.1021/np50097a002

PMID:8377022

Abstract

EtOH extract and purified diterpene andrographolides of Andrographis paniculata (Acanthaceae) induced significant stimulation of antibody and delayed type hypersensitivity (DTH) response to sheep red blood cells (SRBC) in mice. The plant preparations also stimulated nonspecific immune response of the animals measured in terms of macrophage migration index (MMI) phagocytosis of 14C-leucine labelled Escherichia coli and proliferation of splenic lymphocytes. The stimulation of both antigen specific and nonspecific immune response was, however, of lower order with andrographolide than with the EtOH extract, suggesting thereby that substance(s) other than andrographolide present in the extract may also be contributing towards immunostimulation.

摘要

穿心莲（爵床科）的乙醇提取物、纯化的二萜类穿心莲内酯可显著刺激小鼠对绵羊红细胞（SRBC）的抗体及迟发型超敏反应（DTH）。这些植物制剂还能刺激动物的非特异性免疫反应，具体表现为巨噬细胞迁移指数（MMI）、14C-亮氨酸标记的大肠杆菌吞噬作用以及脾淋巴细胞增殖。然而，与乙醇提取物相比，穿心莲内酯对特异性和非特异性免疫反应的刺激作用较弱，这表明提取物中除穿心莲内酯外的其他物质可能也有助于免疫刺激。