Vasseur Francis, Leprêtre Frédéric, Lacquemant Corinne, Froguel Philippe
CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Docteur Calmette, BP 447, F-59021 Lille, France.
Curr Diab Rep. 2003 Apr;3(2):151-8. doi: 10.1007/s11892-003-0039-4.
Adiponectin encoded by the APMI gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APMI gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APMI gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APMI gene and questions that genetic data raise.
由APMI基因编码的脂联素是一种在脂肪细胞中表达的蛋白质，在葡萄糖、脂质和能量代谢的稳态控制中发挥作用。其失调被认为与包括代谢X综合征在内的多种疾病有关，如胰岛素抵抗、肥胖、2型糖尿病和冠状动脉疾病。最近的数据表明脂联素水平存在基因调控，并且APMI基因所在的3q27位点与糖尿病及代谢X综合征的特征存在连锁关系，这表明APMI基因在该综合征中可能发挥作用。在本文中，我们概述了迄今为止可得的结果，并讨论了APMI基因遗传变异起作用的积极证据以及遗传数据引发的问题。
