从一年蓬（Erigeron annuus (L.) PERS.）、毛莲菜（Erigeron philadelphicus L.）和苏门白酒草（Erigeron sumatrensis RETZ.）中分离得到的五种新倍半萜和一种新二萜

Five new sesquiterpenoids and a new diterpenoid from Erigeron annuus (L.) PERS., Erigeron philadelphicus L. and Erigeron sumatrensis RETZ.

作者信息

Iijima Takeyoshi, Yaoita Yasunori, Kikuchi Masao

机构信息

Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2003 May;51(5):545-9. doi: 10.1248/cpb.51.545.

DOI:10.1248/cpb.51.545

PMID:12736454

Abstract

The aerial parts of Erigeron annuus (L.) PERS., E. philadelphicus L. and E. sumatrensis RETZ. (Compositae) have been investigated chemically. A new sesquiterpenoid, 6beta,14-epoxyeudesm-4(15)-en-1beta-ol (1), and a new diterpenoid, philadelphinone (6), have been isolated from E. philadelphicus. Four new sesquiterpenoids, (7R*)-opposit-4(15)-ene-1beta,7-diol (2), 11-methoxyopposit-4(15)-en-1beta-ol (3), 15-methoxyisodauc-3-ene-1beta,5alpha-diol (4) and 10alpha-hydroxycadin-4-en-15-al (5), have been isolated from E. annuus. Compounds 2 and 4 were also isolated from E. sumatrensis. The structures of the new compounds were elucidated on the basis of their spectral data.

摘要

对一年蓬（Erigeron annuus (L.) PERS.）、费城飞蓬（E. philadelphicus L.）和苏门答腊飞蓬（E. sumatrensis RETZ.）（菊科）的地上部分进行了化学研究。从费城飞蓬中分离出一种新的倍半萜类化合物，6β,14-环氧桉叶-4(15)-烯-1β-醇（1），以及一种新的二萜类化合物，费城飞蓬酮（6）。从一年蓬中分离出四种新的倍半萜类化合物，(7R*)-对映-4(15)-烯-1β,7-二醇（2）、11-甲氧基对映-4(15)-烯-1β-醇（3）、15-甲氧基异胡萝卜-3-烯-1β,5α-二醇（4）和10α-羟基杜松-4-烯-15-醛（5）。化合物2和4也从苏门答腊飞蓬中分离得到。根据新化合物的光谱数据阐明了它们的结构。