Demirci Mustafa, Delibas Namik, Altuntas Irfan, Oktem Faruk, Yönden Zafer
Department of Microbiology and Clinical Microbiology, Medical Faculty, Süleyman Demirel University, Isparta, Turkey.
J Health Popul Nutr. 2003 Mar;21(1):72-5.
This study investigated the levels of iron, zinc, and copper and their demolishing effects against lipid peroxidation in chronic giardiasis. Serum iron, zinc and copper levels, erythrocyte cytosolic superoxide dismutase activity, and malondialdehyde levels were measured in 34 children with chronic giardiasis and were compared with controls. The serum iron and zinc levels and erythrocyte superoxide dismutase activity were significantly lower, and malondialdehyde levels were significantly higher among the children with chronic giardiasis compared to the control group (p < 0.001). There was no significant difference in copper levels between the two groups (p > 0.05). Consequently, the oxidant-antioxidant balance may tilt towards the oxidative side due to weakness of the antioxidant system in giardiasis. If early and proper treatment is not performed, free radical-mediated damage might occur in children with chronic giardiasis.
本研究调查了慢性贾第虫病中铁、锌、铜的水平及其对脂质过氧化的破坏作用。测定了34例慢性贾第虫病患儿的血清铁、锌和铜水平、红细胞胞质超氧化物歧化酶活性以及丙二醛水平，并与对照组进行比较。与对照组相比，慢性贾第虫病患儿的血清铁和锌水平以及红细胞超氧化物歧化酶活性显著降低，丙二醛水平显著升高（p < 0.001）。两组之间铜水平无显著差异（p > 0.05）。因此，由于贾第虫病中抗氧化系统的薄弱，氧化-抗氧化平衡可能向氧化方向倾斜。如果不进行早期适当治疗，慢性贾第虫病患儿可能会发生自由基介导的损伤。
