Jacoby Douglas S, Rader Daniel J
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Arch Intern Med. 2003 May 26;163(10):1155-64. doi: 10.1001/archinte.163.10.1155.
The renin-angiotensin system plays a central role in the pathogenesis of cardiovascular disease. At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. Trials in animals and humans indicate that blocking renin-angiotensin system pathways decreases atherosclerotic plaque progression and ischemic events. This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials.
肾素-血管紧张素系统在心血管疾病的发病机制中起核心作用。在分子和细胞水平上，该系统的主要效应肽血管紧张素II会刺激动脉粥样硬化的关键成分。动物和人体试验表明，阻断肾素-血管紧张素系统途径可减少动脉粥样硬化斑块进展和缺血事件。本综述全面概述了肾素-血管紧张素系统在动脉粥样硬化血栓形成疾病中的整体作用，涵盖从分子途径到人类遗传学再到最新临床试验的各个方面。
