Salinas J A, White N M
Department of Psychology, McGill University, Montreal, Quebec, Canada.
Behav Neurosci. 1998 Aug;112(4):812-26. doi: 10.1037//0735-7044.112.4.812.
Rats were trained to run down a runway for either 1 or 10 food pellets. After training, those receiving 10 pellets were shifted to 1 pellet. Such shifts typically elicit a temporary decrease in running speed. Groups of normal rats and rats with bilateral lesions of the fimbria-fornix, lateral-basolateral complex of the amygdala, or dorsal striatum were tested with the shifted and unshifted procedures. Separate experiments, identical except for the intertrial intervals (ITIs; 3 min vs. 30 s), were carried out. The data are consistent with the view that an integrated action of multiple neural systems is required to observe the typical response to reward reduction in unlesioned rats. One system that includes the dorsal striatum promotes a reinforced approach response to the goal box. A neural system that includes fimbria-fornix is required to retain information about reduced reward over the 3-min ITI. A system that includes the amygdala may acquire a conditioned aversive response to the goal box after the shift is detected, leading to reduced speeds over testing.
训练大鼠在跑道上奔跑以获取1颗或10颗食物颗粒。训练后，将原本获取10颗食物颗粒的大鼠改为获取1颗。这种改变通常会导致奔跑速度暂时下降。对正常大鼠组以及海马伞-穹窿、杏仁核外侧基底复合体或背侧纹状体双侧损伤的大鼠组进行了改变和未改变程序的测试。除了试验间隔（ITIs；3分钟与30秒）不同外，进行了单独的相同实验。数据与以下观点一致，即需要多个神经系统的综合作用才能观察到未损伤大鼠对奖励减少的典型反应。一个包括背侧纹状体的系统促进对目标箱的强化趋近反应。一个包括海马伞-穹窿的神经系统需要在3分钟的试验间隔内保留关于奖励减少的信息。一个包括杏仁核的系统可能在检测到改变后对目标箱产生条件性厌恶反应，导致测试期间速度降低。
