Chang Kiki, Steiner Hans, Dienes Kimberly, Adleman Nancy, Ketter Terence
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
Biol Psychiatry. 2003 Jun 1;53(11):945-51. doi: 10.1016/s0006-3223(03)00061-1.
Children of parents with bipolar disorder (bipolar offspring) represent a rich cohort for study with potential for illumination of prodromal forms of bipolar disorder. Due to their high-risk nature, bipolar offspring may present phenomenological, temperamental, and biological clues to early presentations of bipolar disorder. This article reviews the evidence for establishing bipolar offspring as a high-risk cohort, the studies which point to possible prodromal states in bipolar offspring, biological findings in bipolar offspring which may be indicators of even higher risk for bipolar disorder, initial attempts at early intervention in prodromal pediatric bipolar disorder, and implications for future research.
双相情感障碍患者的子女（双相情感障碍后代）是一个丰富的研究群体，有可能为双相情感障碍的前驱形式提供启示。由于其高风险性质，双相情感障碍后代可能为双相情感障碍的早期表现提供现象学、气质和生物学线索。本文综述了将双相情感障碍后代确立为高风险群体的证据、指向双相情感障碍后代可能前驱状态的研究、双相情感障碍后代中可能是双相情感障碍更高风险指标的生物学发现、对前驱期儿童双相情感障碍进行早期干预的初步尝试以及对未来研究的启示。
