Stolk Elly A, Busschbach Jan J V
Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Qual Life Res. 2003 Jun;12(4):363-71. doi: 10.1023/a:1023453405252.
Usually, generic questionnaires such as the EQ-5D or Health Utility Index (HUI) are used to obtain utility scores for computing QALYs. Sometimes, however, application of these instruments is not possible, or the responsiveness is doubted. An alternative strategy is to attribute utility scores to health states of a condition-specific outcomes measure (CSOM). We explored the validity and feasibility of this strategy.
Our samples determined utility scores for the health states of the International Index of Erectile Function (IIEF) using time tradeoff (TTO). To reduce costs and time, the general population (n = 169) was interviewed in groups. We tested the validity of the group sessions in students. To test the extent of agreement between values obtained using the group and those obtained through individual administration, 63 students were interviewed individually and 54 in groups.
The utility scores for the disease-specific health states showed good construct validity. Also, the criterion validity of the adapted TTO was confirmed.
Disease-specific utility scores can be used in QALY analysis by converting them to a generic scale. Efforts should be undertaken to prevent response spreading. Administrating TTO in groups could reduce the time and costs of TTO administration and render the strategy of determining utilities for condition-specific health states more feasible.
通常，诸如EQ-5D或健康效用指数（HUI）等通用问卷用于获取效用得分以计算质量调整生命年（QALY）。然而，有时无法应用这些工具，或者其反应度受到质疑。另一种策略是将效用得分赋予特定疾病结局测量（CSOM）的健康状态。我们探讨了该策略的有效性和可行性。
我们的样本使用时间权衡法（TTO）确定国际勃起功能指数（IIEF）健康状态的效用得分。为了降低成本和节省时间，对普通人群（n = 169）进行了分组访谈。我们在学生中测试了分组访谈的有效性。为了测试分组获得的值与个体访谈获得的值之间的一致程度，对63名学生进行了个体访谈，54名学生进行了分组访谈。
特定疾病健康状态的效用得分显示出良好的结构效度。此外，经调整的TTO的效标效度得到了证实。
特定疾病的效用得分可通过将其转换为通用量表用于QALY分析。应努力防止反应扩散。分组进行TTO可以减少TTO管理的时间和成本，并使确定特定疾病健康状态效用的策略更可行。
