Department of Psychiatry, Section Medical Psychology and Psychotherapy, Erasmus MC University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Faculty of Psychology, YARSI University, Jakarta, Indonesia.
Health Qual Life Outcomes. 2021 Nov 15;19(1):256. doi: 10.1186/s12955-021-01889-4.
The adult versions EQ-5D-3L and EQ-5D-5L have been extensive compared. This is not the case for the EQ-5D youth versions. The study aim was to compare the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients.
A sample of patients 8-16 years old with different diseases and a wide range of disease severity was asked to complete EQ-5D-Y-3L, EQ-5D-Y-5L, PedsQL Generic Core Scale, and selected, appropriate disease-specific instruments, three times. EQ-5D-Y-3L and EQ-5D-Y-5L were compared in terms of: feasibility, (re-)distribution properties, discriminatory power, convergent validity, test-retest reliability, and responsiveness.
286 participating patients suffered from one of the following diseases: major beta-thalassemia, haemophilia, acute lymphoblastic leukaemia, acute illness. Missing responses were comparable between versions of the EQ-5D-Y, suggesting comparable feasibility. The number of patients in the best health state (level profile 11111) was equal in both EQ-5D-Y versions. The projection of EQ-5D-Y-3L scores onto EQ-5D-Y-5L for all dimensions showed that the two additional levels in EQ-5D-Y-5L slightly improved the accuracy of patients in reporting their problems, especially if severe. Convergent validity with PedsQL and disease-specific measures showed that the two EQ-5D-Y versions performed about equally. Test-retest reliability (EQ-5D-Y-3L 0.78 vs EQ-5D-Y-5L 0.84), and sensitivity for detecting health changes, were both better in EQ-5D-Y-5L.
Extending the number of levels did not give clear superiority to EQ-5D-Y-5L over EQ-5D-Y-3L based on the criteria assessed in this study. However, increasing the number of levels benefitted EQ-5D-Y performance in the measurement of moderate to severe problems and especially in longitudinal study designs.
成人版 EQ-5D-3L 和 EQ-5D-5L 已经被广泛比较。而儿童版 EQ-5D 则并非如此。本研究旨在比较青少年版 EQ-5D-Y-3L 和 EQ-5D-Y-5L 在儿科患者中的测量特性和反应度。
本研究招募了患有不同疾病且疾病严重程度差异较大的 8-16 岁患者，要求他们分别三次完成 EQ-5D-Y-3L、EQ-5D-Y-5L、PedsQL 通用核心量表和特定疾病的适宜量表。EQ-5D-Y-3L 和 EQ-5D-Y-5L 在以下方面进行了比较：可行性、（重新）分布特性、判别能力、收敛效度、测试-重测信度和反应度。
共有 286 名患者参与了研究，他们患有以下疾病之一：重型β地中海贫血、血友病、急性淋巴细胞白血病、急性疾病。两种 EQ-5D-Y 版本的缺失响应率相当，提示可行性相当。两种 EQ-5D-Y 版本中，处于最佳健康状态（水平分布 11111）的患者人数相同。EQ-5D-Y-3L 评分在所有维度上投影到 EQ-5D-Y-5L 上，表明 EQ-5D-Y-5L 中的另外两个水平略微提高了患者报告其问题的准确性，尤其是在严重程度较高的情况下。与 PedsQL 和特定疾病的测量指标的收敛效度表明，两种 EQ-5D-Y 版本的表现大致相当。测试-重测信度（EQ-5D-Y-3L 为 0.78，EQ-5D-Y-5L 为 0.84），以及检测健康变化的敏感性，在 EQ-5D-Y-5L 中均更好。
根据本研究评估的标准，增加水平数量并未使 EQ-5D-Y-5L 明显优于 EQ-5D-Y-3L。然而，增加水平数量有益于 EQ-5D-Y 在测量中度至重度问题方面的表现，特别是在纵向研究设计中。
