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纽约市铅基涂料危害整治对铅中毒儿童血铅水平的影响。

The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City.

作者信息

Leighton Jessica, Klitzman Susan, Sedlar Slavenka, Matte Thomas, Cohen Neal L

机构信息

Lead Poisoning Prevention Program, New York City Department of Health, 253 Broadway, 12th floor, Box CN58, 10007, New York, NY 10010, USA.

出版信息

Environ Res. 2003 Jul;92(3):182-90. doi: 10.1016/s0013-9351(03)00036-7.

Abstract

Despite the widespread use of lead paint hazard control for children with lead poisoning, few controlled studies that estimate the effect of such control on children's blood lead levels have been published. This retrospective follow-up study examined the effects of lead hazard remediation and its timing on the blood lead levels of lead-poisoned children. From the New York City child blood lead registry, 221 children were selected who had an initial blood lead level of 20-44 micro g/dL between 1 July 1994 and 31 December 1996; were 6 months to 6 years of age; had a report of a follow-up blood lead test between 10 and 14 months after the initial test; had a lead-based paint hazard identified in the primary dwelling unit prior to the 10- to 14-month follow-up blood lead test; had resided or spent time at only one address with an identified lead-based paint hazard; and were not chelated. The decline in geometric mean blood lead levels from baseline to 10-14 months later was compared for children whose homes were remediated and whose homes were not remediated during the follow-up period. Regardless of remediation, geometric mean blood lead levels declined significantly from 24.3 micro g/dL at the initial diagnosis to 12.3 micro g/dL at the 10- to 14-month follow-up blood lead test (P<0.01). Among the 146 children whose homes were remediated the geometric mean blood lead levels declined 53% compared to 41% among the 75 children whose homes were not remediated by the follow-up blood lead test, a remediation effect of approximately 20% (P<0.01). After adjusting for potential confounders, the remediation effect was 11%, although it was no longer significant. Race was the only factor that appeared to confound the relationship: Black children had higher follow-up blood lead levels even after controlling for other factors, including the natural logarithm of the initial blood lead level. The effect of remediation appeared to be stronger for younger (10 to <36 months old) than for older (36 to 72 months old) children (P=0.06). While children in homes with earlier remediation (within less than 3 months) appeared to have greater declines in blood lead levels at the follow-up test than children in homes with later remediation (after 3 or more months), this trend was not significant when controlling for confounding factors. The findings of this study suggest that early identification of lead-poisoned children and timely investigation and abatement of hazards contribute to reducing blood lead levels. However, the apparent effect is modest and further research is needed to systematically test and improve the effectiveness of lead hazard controls.

摘要

尽管针对铅中毒儿童广泛采用了铅涂料危害控制措施,但很少有对照研究发表,以评估此类控制措施对儿童血铅水平的影响。这项回顾性随访研究考察了铅危害整治及其时机对铅中毒儿童血铅水平的影响。从纽约市儿童血铅登记处选取了221名儿童,他们在1994年7月1日至1996年12月31日期间的初始血铅水平为20 - 44微克/分升;年龄在6个月至6岁之间;在初始检测后10至14个月之间有随访血铅检测报告;在10至14个月的随访血铅检测之前,在主要居住单元中发现了铅基涂料危害;仅居住或在有已识别铅基涂料危害的一个地址停留过;且未进行过螯合治疗。比较了在随访期间家中进行整治和未进行整治的儿童从基线到10 - 14个月后几何平均血铅水平的下降情况。无论是否进行整治,几何平均血铅水平从初始诊断时的24.3微克/分升显著下降至10至14个月随访血铅检测时的12.3微克/分升(P<0.01)。在146名家中进行了整治的儿童中,几何平均血铅水平下降了53%,相比之下,在75名家中未进行整治的儿童中这一比例为41%,整治效果约为20%(P<0.01)。在对潜在混杂因素进行调整后,整治效果为11%,尽管不再具有统计学显著性。种族似乎是唯一混淆这种关系的因素:即使在控制了其他因素,包括初始血铅水平的自然对数之后,黑人儿童的随访血铅水平仍较高。整治效果在年龄较小(10至<36个月)的儿童中似乎比年龄较大(36至72个月)的儿童更强(P = 0.06)。虽然家中整治较早(在不到3个月内)的儿童在随访检测时血铅水平的下降似乎比家中整治较晚(3个月或更长时间后)的儿童更大,但在控制混杂因素后,这一趋势并不显著。本研究结果表明,早期识别铅中毒儿童并及时调查和消除危害有助于降低血铅水平。然而,明显效果较为有限,需要进一步研究来系统地测试和提高铅危害控制措施的有效性。

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