Wong S N, Yu E C, Lok A S, Chan K W, Lau Y L
Department of Paediatrics, University of Hong Kong.
Pediatr Nephrol. 1992 Sep;6(5):417-20. doi: 10.1007/BF00873997.
Two Chinese boys, aged 3.5 and 5 years, developed nephrotic syndrome and were chronic carriers of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg). Renal biopsy showed membranous glomerulonephritis and liver biopsy showed chronic persistent hepatitis. They were given interferon-alpha-2a at a dose of 5 MU/m2 on alternate days for 12 and 16 weeks after 2 years of persistent nephrotic syndrome. Patient 1 showed complete remission and resolution of hepatosplenomegaly, but his serum remained positive for HBsAg, HBeAg and hepatitis B virus DNA. Patient 2 showed only a transient clinical response and seroconversion from HBeAg to anti-HBe status. Although not always successful, interferon treatment should be considered in severe persistent nephrotic states, since there is at present no satisfactory treatment for this form of glomerulonephropathy.
两名中国男孩，年龄分别为3.5岁和5岁，患肾病综合征，且为乙肝病毒表面抗原（HBsAg）和乙肝病毒e抗原（HBeAg）慢性携带者。肾活检显示为膜性肾小球肾炎，肝活检显示为慢性持续性肝炎。在持续性肾病综合征2年后，他们接受了α-2a干扰素治疗，剂量为5 MU/m²，隔日一次，持续12周和16周。患者1实现了完全缓解，肝脾肿大消退，但血清HBsAg、HBeAg和乙肝病毒DNA仍为阳性。患者2仅出现短暂的临床反应，且HBeAg血清学转换为抗-HBe状态。尽管干扰素治疗并非总是成功，但对于严重的持续性肾病状态应考虑使用，因为目前对于这种类型的肾小球肾炎尚无令人满意的治疗方法。
