Moraes R, Corá L A, Américo M F, Oliveira R B, Baffa O, Miranda J R A
Department of Physics and Biophysics, Laboratory of Biomag, Instituto de Biociências, Universidade Estadual Paulista, Unesp, PO Box 510, Botucatu, SP 18618-000, Brazil.
Physiol Meas. 2003 May;24(2):337-45. doi: 10.1088/0967-3334/24/2/309.
The mechanical nature of gastric contraction activity (GCA) plays an important role in gastrointestinal motility. The aim of this study was to detect GCA in anaesthetized dogs, using simultaneously the techniques of AC biosusceptometry (ACB) and manometry, analysing the characteristics of frequency and amplitude (motility index) of GCA, modified by drugs such as prostigmine and N-butyl-scopolamine. The ACB method is based on a differential transformer of magnetic flux and the magnetic tracer works as a changeable external nucleus. This magnetic tracer causes a modification in the magnetic flux, which is detected by the coils. The results obtained from the ACB showed a performance comparable to the manometry in measuring the modifications in the frequency and amplitude of the GCA. We concluded that this ACB technique, non-invasive and free of ionizing radiation, is an option for evaluating GCA and can be employed in future clinical studies.
胃收缩活动（GCA）的力学性质在胃肠动力中起着重要作用。本研究的目的是在麻醉犬中检测GCA，同时使用交流生物电阻抗测量法（ACB）和测压技术，分析被新斯的明和丁溴东莨菪碱等药物改变的GCA频率和幅度（动力指数）特征。ACB方法基于磁通量差动变压器，磁示踪剂作为可变外部核起作用。该磁示踪剂会引起磁通量变化，由线圈检测到。ACB获得的结果表明，在测量GCA频率和幅度变化方面，其性能与测压相当。我们得出结论，这种无创且无电离辐射的ACB技术是评估GCA的一种选择，可用于未来的临床研究。
