一项关于吸烟者和饮酒者饮用绿茶与降低消化道癌症风险的病例对照研究

[A case-control study on drinking green tea and decreasing risk of cancers in the alimentary canal among cigarette smokers and alcohol drinkers].

作者信息

Mu Li-na, Zhou Xue-fu, Ding Bao-guo, Wang Ru-hong, Zhang Zuo-feng, Chen Chuan-wei, Wei Guo-rong, Zhou Xiao-ming, Jiang Qing-wu, Yu Shun-zhang

机构信息

School of Public Health, Fudan University, Shanghai 200032, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Mar;24(3):192-5.

PMID:12816709

Abstract

OBJECTIVE

To explore the role of green tea in decreasing the risks of gastric cancer, liver cancer, esophageal cancer among alcohol drinkers or cigarette smokers.

METHODS

A population based case-control study was conducted in Taixing, Jiangsu province.

RESULTS

In Taixing city, identified cases of stomach, liver and esophageal cancers were chosen with informed consent. The numbers were 206, 204, 218 respectively. Controls were chosen from normal population having lived in the area for longer than 10 years, also with informed consent. Green tea drinking seemed to have decreased 81%, 78%, 39% risk for the development of gastric cancer, liver cancer and esophageal cancer among alcohol drinkers. It might also have decreased 16%, 43%, 31% on the risks of developing the three kinds of cancers among cigarette smokers. Interaction assessment showed that drinking green tea could significantly decrease the risk of gastric cancer and liver cancer among alcohol drinkers, with ORs of interaction item 0.23 (95% CI: 0.10 - 0.55) and 0.25 (95% CI: 0.11 - 0.57) respectively.

CONCLUSION

Habit of drinking green tea seemed to have significant protective effects on the development of both gastric and liver cancer among alcohol drinkers while, green tea also having some protective effect on esophageal cancer among alcohol drinkers and on three kinds of cancers among cigarette smokers.

摘要

目的

探讨绿茶在降低饮酒者或吸烟者患胃癌、肝癌、食管癌风险中的作用。

方法

在江苏省泰兴市开展一项基于人群的病例对照研究。

结果

在泰兴市，选取了经知情同意的胃癌、肝癌和食管癌确诊病例，数量分别为206例、204例、218例。对照组从在该地区居住超过10年的正常人群中选取，同样经知情同意。饮用绿茶似乎使饮酒者患胃癌、肝癌和食管癌的风险分别降低了81%、78%、39%。它可能也使吸烟者患这三种癌症的风险分别降低了16%、43%、31%。交互作用评估显示，饮用绿茶可显著降低饮酒者患胃癌和肝癌的风险，交互作用项的比值比分别为0.23（95%可信区间：0.10 - 0.55）和0.25（95%可信区间：0.11 - 0.57）。