Choi Jongsik, Bogdanski Denise, Köller Manfred, Esenwein Stefan A, Müller Dietmar, Muhr Gert, Epple Matthias
Solid State Chemistry, Faculty of Chemistry, University of Bochum, Universitaetsstr. 150, D-44780, Bochum, Germany.
Biomaterials. 2003 Sep;24(21):3689-96. doi: 10.1016/s0142-9612(03)00241-2.
Nickel-titanium shape-memory alloys (NiTi-SMA) were coated with calcium phosphate by dipping in oversaturated calcium phosphate solution. The layer thickness (typically 5-20 micrometer) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to withstand both the shape-memory transition upon cooling and heating and also strong bending of the material (superelastic effect). This layer may improve the biocompatibility of NiTi-SMA, particulary for osteosynthetic devices by creating a more physiological surface and by restricting a potential nickel release. The adherence of human leukocytes (peripheral blood mononuclear cells and polymorphonuclear neutrophil granulocytes) and platelets to the calcium phosphate layer was analyzed in vitro. In comparison to non-coated NiTi-SMA, leukocytes and platelets showed a significantly increased adhesion to the coated NiTi-SMA.
通过将镍钛形状记忆合金（NiTi-SMA）浸入过饱和磷酸钙溶液中，在其表面涂覆磷酸钙。通过选择浸泡时间，可以改变涂层厚度（通常为5-20微米）。微晶层的多孔性质使其在机械上足够稳定，能够承受冷却和加热时的形状记忆转变以及材料的强烈弯曲（超弹性效应）。该层可以通过创造更接近生理状态的表面并限制潜在的镍释放，来提高NiTi-SMA的生物相容性，特别是对于骨合成装置。体外分析了人白细胞（外周血单核细胞和多形核中性粒细胞）和血小板对磷酸钙层的粘附情况。与未涂层的NiTi-SMA相比，白细胞和血小板对涂层NiTi-SMA的粘附显著增加。
