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Treatment of meningococcal infection.脑膜炎球菌感染的治疗。
Arch Dis Child. 2003 Jul;88(7):608-14. doi: 10.1136/adc.88.7.608.
2
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An overview of meningitis and meningococcal septicaemia.脑膜炎和脑膜炎球菌败血症概述。
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Mild meningococcaemia, pyrexia protocols and a problematic public health response.轻度脑膜炎球菌血症、发热治疗方案及有问题的公共卫生应对措施。
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Arch Dis Child. 2003 Jul;88(7):601-7. doi: 10.1136/adc.88.7.601.

本文引用的文献

1
Pathophysiology of meningococcal meningitis and septicaemia.脑膜炎球菌性脑膜炎和败血症的病理生理学
Arch Dis Child. 2003 Jul;88(7):601-7. doi: 10.1136/adc.88.7.601.
2
Assessing the use of activated protein C in the treatment of severe sepsis.评估活化蛋白C在严重脓毒症治疗中的应用。
N Engl J Med. 2002 Sep 26;347(13):1030-4. doi: 10.1056/NEJMsb021512.
3
When to do a lumbar puncture.何时进行腰椎穿刺。
Arch Dis Child. 2002 Sep;87(3):235-7. doi: 10.1136/adc.87.3.235.
4
The role of lumbar puncture in suspected CNS infection--a disappearing skill?腰椎穿刺在疑似中枢神经系统感染中的作用——一项正在消失的技能？
Arch Dis Child. 2002 Sep;87(3):181-3. doi: 10.1136/adc.87.3.181.
5
The meningococcus tamed?脑膜炎球菌被驯服了？
Arch Dis Child. 2002 Jul;87(1):13-7. doi: 10.1136/adc.87.1.13.
6
Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock.儿童和新生儿感染性休克血流动力学支持的临床实践参数
Crit Care Med. 2002 Jun;30(6):1365-78. doi: 10.1097/00003246-200206000-00040.
7
Psychiatric adjustment following meningococcal disease treated on a PICU.
Intensive Care Med. 2002 May;28(5):648-50. doi: 10.1007/s00134-002-1237-2. Epub 2002 Mar 27.
8
Investigation for complement deficiency following meningococcal disease.脑膜炎球菌病后补体缺陷的调查。
Arch Dis Child. 2002 Mar;86(3):215-7. doi: 10.1136/adc.86.3.215.
9
Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease.脑膜炎球菌病患儿促肾上腺皮质激素和皮质醇水平与炎症反应及疾病严重程度的关系
J Infect Dis. 2001 Dec 15;184(12):1532-7. doi: 10.1086/324673. Epub 2001 Dec 3.
10
Reduction in case fatality rate from meningococcal disease associated with improved healthcare delivery.与医疗服务改善相关的脑膜炎球菌病病死率降低。
Arch Dis Child. 2001 Nov;85(5):386-90. doi: 10.1136/adc.85.5.386.

脑膜炎球菌感染的治疗。

Treatment of meningococcal infection.

作者信息

Welch S B, Nadel S

机构信息

Department of Paediatrics, Faculty of Medicine, Imperial College London, St Mary's Hospital, London, UK.

出版信息

Arch Dis Child. 2003 Jul;88(7):608-14. doi: 10.1136/adc.88.7.608.

DOI:10.1136/adc.88.7.608
PMID:12818909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1763151/
Abstract

Aggressive early treatment of meningococcal disease can reduce mortality. This relies on prompt recognition and treatment of the complications of septicaemia and meningitis, appropriate ongoing intensive care where necessary, and adequate management of multiple organ failure. Most children with meningococcal disease survive intact, but long term sequelae are increasingly recognised and make follow up essential. New treatments continue to be evaluated, but none has so far proven to be effective in further reducing morbidity or mortality. Simple, timely therapeutic manoeuvres may greatly improve the prospects for survival.

摘要

对脑膜炎球菌病进行积极的早期治疗可降低死亡率。这依赖于对败血症和脑膜炎并发症的及时识别与治疗、必要时适当的持续重症监护以及对多器官功能衰竭的充分管理。大多数患脑膜炎球菌病的儿童可完全康复，但长期后遗症越来越受到关注，因此随访至关重要。新的治疗方法仍在不断评估中，但迄今为止，尚无一种方法被证明能进一步降低发病率或死亡率。简单、及时的治疗措施可能会大大改善生存前景。